In this paper, we combine the latest observational data, including the WMAP five-year data (WMAP5), BOOMERanG, CBI, VSA, ACBAR, as well as the Baryon Acoustic Oscillations (BAO) and Type Ia Supernoave (SN) "Union" compilation (307 sample), and use the Markov Chain Monte Carlo method to determine the cosmological parameters, such as the equation-of-state (EoS) of dark energy, the curvature of universe, the total neutrino mass and the parameters associated with the power spectrum of primordial fluctuations. Our results show that the ΛCDM model remains a good fit to the current data. In a flat universe, we obtain the tight limit on the constant EoS of dark energy as, w = −0.977 ± 0.056 (1 σ). For the dynamical dark energy models with time evolving EoS parameterized as w de (a) = w0 + w1(1 − a), we find that the best-fit values are w0 = −1.08 and w1 = 0.368, implying the preference of Quintom model whose EoS gets across the cosmological constant boundary during evolution. For the curvature of universe Ω k , our results give −0.012 < Ω k < 0.009 (95% C.L.) when fixing w de = −1. When considering the dynamics of dark energy, the flat universe is still a good fit to the current data, −0.015 < Ω k < 0.018 (95% C.L.). Regarding the neutrino mass limit, we obtain the upper limits, mν < 0.533 eV (95% C.L.) within the framework of the flat ΛCDM model. When adding the SDSS Lyman-α forest power spectrum data, the constraint on mν can be significantly improved, mν < 0.161 eV (95% C.L.). However, these limits can be weakened by a factor of 2 in the framework of dynamical dark energy models, due to the obvious degeneracy between neutrino mass and the EoS of dark energy model. Assuming that the primordial fluctuations are adiabatic with a power law spectrum, within the ΛCDM model, we find that the upper limit on the ratio of the tensor to scalar is r < 0.200 (95% C.L.) and the inflationary models with the slope ns ≥ 1 are excluded at more than 2 σ confidence level. However, in the framework of dynamical dark energy models, the allowed region in the parameter space of (ns,r) is enlarged significantly. Finally, we find no strong evidence for the large running of the spectral index, αs = −0.019 ± 0.017 (1 σ) for the ΛCDM model and αs = −0.023 ± 0.019 (1 σ) for the dynamical dark energy model, respectively.