Weight-bearing and non-weight-bearing pain may reflect different pain mechanisms in knee osteoarthritis

Objective. To evaluate the efficacy and adverse reactions of arthroscopic half-moon plate invasive surgery (DEB) in patients with knee pain (AKP) using meta-analysis techniques. Methods. The computer retrieves from the English databases PubMed, EMBASE, Cochrane Library, and Web of Science and the Chinese databases China Knowledge Network, Wanfang Database, VIP Database, and China Biomedical Literature Database to collect information about DEB therapeutic AKP randomized controlled trial. Develop criteria for documentation inclusion and exclusion, evaluate the quality and bias risk of literature, and compare differences in efficacy and adverse responses before and after DEB treatment and other conservative treatments. Results. A total of 14 randomized controlled trials and 1464 AKP patients were included in the study, with follow-up duration of 1-12 months. The total knee scores for DEB at 1, 3, 6, and 12 months after treatment were significantly better than baseline levels (1 month: WMD = 34.56 , P = 0.02 ; 3 months: WMD = 27.73 , P = 0.0001 ; 6 months: SMD = 2.38 , P = 0.0001 ; 12 months: SMD = 1.69 , P = 0.001 ). At 6 months of follow-up, DEB improved knee function better than HA ( SMD = 0.47 , P = 0.003 ), and during follow-up for 12 months, DEB relieved knee pain ( SMD = 0.55 , P = 0.0007 ) and improved knee function ( SMD = 0.88 , P = 0.0001 ) which is significantly better than HA. DEB was less effective at improving knee function in 1, 3, and 12 months than DEB joint HA injections (1 month P = 004 ; 3 months P = 0.01 ; 12 months P = 0.03 ). At 6 and 12 months of follow-up, DEB was better at pain relief and improved function than ozone ( P > 0.05 ). DEB and glucocorticosteroids have similar effects in pain relief and improved function at various follow-up times. In terms of adverse reactions, DEB does not increase the risk of adverse events compared to HA ( OR = 0.96 , P = 0.85 ). Conclusion. Compared to HA and ozone, DEB is a more effective treatment for AKP joints, while DEB is combined with HA. The clinical efficacy of injection therapy AKP is better than that of DEB alone.

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“…We use Egger tests to evaluate publication bias. When the P value < 0.05, the result is considered statistically significant [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Sun

Huang²

2022

Applied Bionics and Biomechanics

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“…Weight-bearing pain has been described as more likely to reflect biochemical mechanisms triggered by tissue damage leading to nociceptive pain, 4 , 5 , 11 whereas the pathology of non–weight-bearing pain continues to be poorly understood. It has been hypothesized to arise as a neuroplastic response to the chronicity of nociceptive input from the subchondral bone marrow lesions 2 albeit this hypothesis has been challenged in a recent experimental study 1 suggesting the etiology of non–weight-bearing pain could be more complex and potentially at least partly due to a proinflammatory response to tissue damage. The middle range of the VAS scale, ie, 20 to 80 (0–100 scale) correlated poorly to the WOMAC pain scale overall, suggesting that the complicated cognitive abstraction required in scoring pain in the intermediate range contributed to this finding, although the potential explanations for this observation were not possible to study in the current data set.…”

Section: Discussionmentioning

confidence: 99%

Associations between single-question Visual Analogue Scale pain score and weight-bearing and non–weight-bearing domains of Western Ontario and McMaster Universities Arthritis Index pain: data from 2 phase 3 clinical trials

Bjerre-Bastos

Miller

et al. 2022

PR9

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Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial

Aoyagi,

Rivas,

Shababi

et al. 2025

Osteoarthritis and Cartilage Open

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Weight-bearing and non-weight-bearing pain may reflect different pain mechanisms in knee osteoarthritis

Cited by 3 publications

References 0 publications

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Associations between single-question Visual Analogue Scale pain score and weight-bearing and non–weight-bearing domains of Western Ontario and McMaster Universities Arthritis Index pain: data from 2 phase 3 clinical trials

Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial

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