Weight Change Trajectory in Patients With Locally Advanced Nasopharyngeal Carcinoma During the Peri–Radiation Therapy Period

Zhang, Xiaoxia; Liu, Juan; Yu, Haiyang; Su, Xiaotian; Chen, Hongxiu; He, Youwei; Liu, Zhe; Hu, Xiuying

doi:10.1188/21.onf.65-79

Cited by 3 publications

(4 citation statements)

References 59 publications

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“…Nasopharyngeal carcinoma (NPC) is a common clinical malignancy occurring in the mucosal epithelium of the nasopharynx, and is particularly common in the southern region of China [ 1 ]. Epidemiological trends in recent years have shown that its incidence and mortality have increased year by year, posing a serious threat to people's health and life [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological trends in recent years have shown that its incidence and mortality have increased year by year, posing a serious threat to people's health and life [ 2 ]. The latest statistics show that there were more than 60,000 new cases of nasopharyngeal carcinoma diagnosed in China in 2018, with the incidence rate in men being about 2.5 times higher than that in women, and it is more common in people between the ages of 40 and 50 [ 1 ]. Nasopharyngeal cancer has significant geographical and ethnic differences and has a tendency to cluster in families, with descendants of overseas Chinese who have migrated to low-incidence areas still having a high propensity to develop the disease [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Chen

Yao

Ding

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effects of self-care plus forecasting nursing on the treatment outcomes and emotions in nasopharyngeal carcinoma patients undergoing radiotherapy. Methods. Eighty nasopharyngeal carcinoma patients after radiotherapy admitted to our hospital from February 2020 to August 2021 were selected. The patients were allocated into an observation group (n = 40) and an experimental group (n = 40) according to different nursing protocols. The observation group received traditional nursing intervention, whereas the experimental group received self-care plus forecasting nursing intervention. The levels of the indexes (quality of life, score on the Zung Self-Rating Anxiety Scale (SAS), score on the Zung Self-Rating Depression Scale (SDS), and adverse reaction) were compared between the two groups. Results. The score of the experimental group for the quality of life was significantly higher than that of the observation group ( P < 0.05 ); the SAS and SDS scores of the experimental group after nursing intervention were significantly lower than those of the observation group ( P < 0.05 ); the incidence of adverse reactions in the experimental group during radiotherapy was significantly lower than that of the observation group ( P < 0.05 ). Conclusion. The self-care plus forecasting nursing intervention is effective in postradiotherapy patients with nasopharyngeal carcinoma. The technique is proved effective to improve the quality of life, reduce anxiety and depression, and decrease the incidence of adverse reactions in patients during treatment. These features make the technique worthy of a wider clinical application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Chen

Yao

Ding

2022

Evidence-Based Complementary and Alternative Medicine

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Section: Discussionmentioning

confidence: 99%

“…The GP and TPF regimens can reduce the incidence of CWL, which may be because these 2 regimens are administered every 21 days per cycle, and the relatively long interval is helpful for body weight recovery. 15 Because smoking is related to a poor prognosis and a poor treatment effect of NPC, 32 we first focused on the relationship between smoking status and weight loss in our research, but our study suggests that the association between smoking and NPC is limited, which is consistent with the results of Tang et al 32 Peng et al 33 found that Epstein-Barr virus (EBV) DNA has good prognostic value in a long-term survival study of NPC patients after IMRT, but our study found that this index has no significance for predicting the incidence of CWL in patients. This study still has certain limitations, including survivor bias, the exclusion of patients with more serious complications, and a failure to evaluate factors related to weight changes (such as caloric intake and daily activities).…”

Section: Discussionmentioning

confidence: 99%

A Nomogram to Predict Critical Weight Loss in Patients with Nasopharyngeal Carcinoma During (Chemo) Radiotherapy

Huang

Chen

Zhang

et al. 2022

Clin Med Insights Oncol

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Background: Weight loss is an important side effect of long-term anticancer treatment for nasopharyngeal carcinoma patients. The decline in body function will cause many adverse effects, such as local recurrence and distant metastasis, and reduce the patient’s quality of life. Therefore, this study developed a predictive model for the probability of critical weight loss to provide timely appropriate nutritional interventions and prevent serious side effects. Methods: A 20-week prospective follow-up study of 137 nasopharyngeal carcinoma patients in West China Hospital of Sichuan University undergoing radiotherapy and chemotherapy from February 2018 to March 2020 was conducted to collect relevant clinical data. The clinical usefulness and calibration of the prediction model were assessed using the C-index, calibration plot, receiver operating curve, and decision curve analysis. Internal validation was assessed using bootstrapping validation. Results: The nomogram consisted of sex, smoking status, physical status, chemotherapy regimen, and body mass index. Good calibration was observed for the cohort, with an area under the curve of 0.924. Five independent prognostic factors were included in the nomogram, which showed a high C-index value of 0.815 in the interval validation. Decision curve analysis showed that the nomogram was clinically useful when the intervention was decided at the critical weight loss possibility threshold in the 0% to 97% range. Conclusions: We constructed and validated a nomogram for predicting the incidence of critical weight loss in nasopharyngeal cancer patients undergoing chemotherapy and radiotherapy.

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Analysis of nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis

Ma,

Zhao,

Qian

et al. 2023

World J Gastrointest Surg

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BACKGROUND Radiation enteritis, which often occurs during radiation-induced acute intestinal symptoms (RIAIS), is the most common and important complication during radiotherapy for cervical cancer. RIAIS caused by abdominal and pelvic radiotherapy will affect nutrient intake, digestion, absorption, and metabolism, leading to malnutrition or poorer nutritional status. In patients with malignant tumors, malnutrition can adversely affect the curative effect and response of radiotherapy by reducing radiosensitivity, affecting the precision of radiotherapy placement and increasing the incidence of radiotherapy-related adverse reactions. AIM To analyze nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis. METHODS Fifty patients with cervical cancer received external beam radiotherapy, and 15 patients received brachytherapy after external beam radiotherapy. Body weight, body composition parameters, nutritional risk screening (NRS) 2002 score, and blood biochemical indices of patients with cervical cancer during periradiation were tested by a one-way repeated measures analysis of variance. Metabolomics analysis was used to identify characteristic lipid metabolism pathways. Clinical factors that affect linoleic acid changes were screened using the generalized evaluation equation. RESULTS Among the 50 patients, 37 had RIAIS, including 34 patients with grade 1-2 RIAIS and 3 patients with grade 3 RIAIS. The NRS 2002 score of patients who underwent cervical cancer radiotherapy continued to increase during the periradiation period, and 42 patients who underwent cancer radiotherapy had nutritional deficits (NRS 2002 score ≥ 3 points) at the end of radiotherapy. Correlation analyses revealed that body weight and body mass index changes were closely associated with body fat content (R 2 = 0.64/0.51). The results of the univariate analysis showed that radiotherapy time, percentage reduction of serum albumin, and percentage reduction of serum prealbumin were the key factors affecting skeletal muscle exhaustion (P < 0.05). Metabolomic analysis of fecal supernatants of cervical cancer patients during the periradiation period revealed the involvement of linoleic acid, cholic acid, arachidonic acid, and N-acetyl-L-benzene alanine in the metabolic pathway of linoleic acid. CONCLUSION Cervical cancer radiotherapy patients faced nutritional risks, decreased serum albumin synthesis, and increased risk of skeletal muscle exhaustion. Linoleic acid was a biomarker of high nutritional risk.

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Weight Change Trajectory in Patients With Locally Advanced Nasopharyngeal Carcinoma During the Peri–Radiation Therapy Period

Cited by 3 publications

References 59 publications

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

A Nomogram to Predict Critical Weight Loss in Patients with Nasopharyngeal Carcinoma During (Chemo) Radiotherapy

Analysis of nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis

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