Weight Gain Alters Adiponectin Receptor 1 Expression on Adipose Tissue‐Resident Helios+ Regulatory T Cells

Abstract

Adipose tissue produces multiple mediators that modulate the immune response.

Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes

“…Interestingly, impaired adiponectin signalling has been reported at both receptor and post-receptor levels. For example, adiponectin receptor 1 has been shown to be expressed on adipose tissue-resident Tregs, and this expression is negatively correlated with epididymal fat mass even in the absence of significant changes in serum adiponectin [40]. Although dWAT-Tregs have not been investigated, it is possible that in our model, increased adiposity also associates with changes in local immunoregulation via reduced adiponectin sensitivity of dWAT-resident Tregs.…”

Role of Metabolism in the Immunobiology of Regulatory T Cells

“…Adiponectin-deficient mice developed worse EAE and greater central nervous system (CNS) inflammation, demyelination and axon injury together with a defect in Treg cell number and function (80). In this context, Ramos-Ramírez et al showed that adipose tissue resident Treg cells expressed higher levels of adiponectin receptor 1 (AdipoR1) than Treg cells in the spleen, and adipoR1 expression on adipose tissue Helios + Treg cells was negatively correlated with epididymal fat (81). In conclusion, these data suggest that mediators involved in the regulation of food intake have affect Treg cell metabolism.…”

Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation

“…T regs can be identified in tissue with expression of Foxp3 in CD3+ CD4+ cells (Ramos-Ramírez et al, 2016). Regulatory T cells have been deemed a crucial part of the immune system due to their aid in the control of autoimmunity and allergies (Feuerer et al, 2009).…”