Weight, CYP3A5 Genotype, and Voriconazole Co-administration Influence Tacrolimus Initial Dosage in Pediatric Lung Transplantation Recipients with Low Hematocrit based on a Simulation Model
Ke Hu,
Jia-Jun Pan,
Wen-Qian Qu
et al.
Abstract:Objective:
The method of administering the initial doses of tacrolimus in recipients of pediatric
lung transplantation, especially in patients with low hematocrit, is not clear. The present study aims to explore
whether weight, CYP3A5 genotype, and voriconazole co-administration influence tacrolimus initial dosage in
recipients of pediatric lung transplantation with low hematocrit based on safety and efficacy using a simulation
model.
Methods:
The present study utilized the tacrolimus population pharmacokine… Show more
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