Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Meng, Weilun; Peng, Ronggang; Du, Lei; Zheng, Yonglai; Liu, Diya; Qu, Shen; Zhang, Yi

doi:10.3389/fendo.2021.799537

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Additionally, weight loss can alleviate endoplasmic reticulum stress-induced myocardial cell apoptosis, resulting in more orderly and denser arrangement of myocardial cells and promoting intracellular Ca 2+ homeostasis, thereby reducing myocardial autophagy and ventricular remodeling (27). Furthermore, researchers have observed improvement in microcirculation in overweight individuals after the administration of GLP-1RA, which was not observed in individuals with normal or low body weight (28). Microcirculation dysfunction is crucial for ventricular remodeling.…”

Section: Effect Of Glp-1ra On Cardiac Structurementioning

confidence: 99%

GLP-1RA may have varying effects on cardiac structure in patients with ASCVD depending on BMI

Xu,

Zhu

2024

Front. Endocrinol.

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BackgroundGlucagon-like peptide-1 receptor agonist(GLP-1RA) is commonly used in patients with cardiovascular disease due to its significant improvement in the prognosis of atherosclerotic cardiovascular disease (ASCVD). However, previous studies have primarily focused on obese patients, leaving uncertainty regarding whether GLP-1RA can yield similar cardiovascular benefits in individuals with normal or low body weight.MethodsIn this study, we enrolled patients with ASCVD to establish a retrospective cohort. Patients receiving GLP-1RA treatment were assigned to the GLP-1RA group, while a control group was formed by matching age and body mass index (BMI) among patients not receiving GLP-1RA treatment. Each group was further divided into subgroups based on baseline BMI levels: normal weight, overweight, and obesity. A six-month follow-up was conducted to assess changes in patient weight, metabolic indicators, and cardiac structure and function.ResultsAmong the normal weight subgroup, no significant weight change was observed after six months of GLP-1RA treatment (57.4 ± 4.8 vs. 58.7 ± 9.2, p = 0.063). However, significant weight reduction was observed in the other two subgroups (Overweight group: 70.0 ± 9.1 vs. 73.1 ± 8.2, p = 0.003, Obesity group: 90.5 ± 14.3 vs. 95.5 ± 16.6, p<0.001). Regardless of baseline BMI levels, GLP-1RA demonstrated significant glucose-lowering effects in terms of metabolic indicators. However, GLP-1RA have a more significant effect on improving blood lipids in overweight and obese patients. The effects of GLP-1RA on cardiac structure exhibited variations among patients with different baseline BMI levels. Specifically, it was observed that the improvement in atrial structure was more prominent in patients with normal body weight(LAD: 33.0 (30.3, 35.5) vs. 35.0 (32.5, 37.1), p = 0.018, LAA (18.0 (16.0, 21.5) vs. 18.5 (16.5, 20.5), p = 0.008), while the enhancement in ventricular structure was more significant in obese subjects(LEVDD: 49.8 ± 5.8 vs. 50.2 ± 5.0, p < 0.001, LVMI: 65.1 (56.2, 71.4) vs. 65.8 (58.9, 80.4), p < 0.039).ConclusionAccording to the study, it was found that the administration of GLP-1RA can have different effects on cardiac structure in patients with different baseline BMI, In obese patients, improvements in ventricular remodeling may be more associated with weight loss mechanisms, while in patients with normal or low BMI, GLP-1RA may directly improve atrial remodeling through GLP-1 receptors in atrial tissue.

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Section: Effect Of Glp-1ra On Cardiac Structurementioning

confidence: 99%

GLP-1RA may have varying effects on cardiac structure in patients with ASCVD depending on BMI

Xu,

Zhu

2024

Front. Endocrinol.

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The Impact of Bariatric Surgery on Cardiac Structure, and Systolic and Diastolic Function in Patients with Obesity: A Systematic Review and Meta-analysis

Esparham

Shoar²,

Kheradmand

et al. 2022

OBES SURG

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The effects of bariatric surgery on cardiac function: a systematic review and meta-analysis

Sargsyan,

Chen,

Aggarwal

et al. 2023

Int J Obes

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Introduction Obesity is associated with alterations in cardiac structure and haemodynamics leading to cardiovascular mortality and morbidity. Culminating evidence suggests improvement of cardiac structure and function following bariatric surgery. Objective To evaluate the effect of bariatric surgery on cardiac structure and function in patients before and after bariatric surgery. Methods Systematic review and meta-analysis of studies reporting pre- and postoperative cardiac structure and function parameters on cardiac imaging in patients undergoing bariatric surgery. Results Eighty studies of 3332 patients were included. Bariatric surgery is associated with a statistically significant improvement in cardiac geometry and function including a decrease of 12.2% (95% CI 0.096–0.149; p < 0.001) in left ventricular (LV) mass index, an increase of 0.155 (95% CI 0.106–0.205; p < 0.001) in E/A ratio, a decrease of 2.012 mm (95% CI 1.356–2.699; p < 0.001) in left atrial diameter, a decrease of 1.16 mm (95% CI 0.62–1.69; p < 0.001) in LV diastolic dimension, and an increase of 1.636% (95% CI 0.706–2.566; p < 0.001) in LV ejection fraction after surgery. Conclusion Bariatric surgery led to reverse remodelling and improvement in cardiac geometry and function driven by metabolic and haemodynamic factors.

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Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Cited by 3 publications

References 32 publications

GLP-1RA may have varying effects on cardiac structure in patients with ASCVD depending on BMI

GLP-1RA may have varying effects on cardiac structure in patients with ASCVD depending on BMI

The Impact of Bariatric Surgery on Cardiac Structure, and Systolic and Diastolic Function in Patients with Obesity: A Systematic Review and Meta-analysis

The effects of bariatric surgery on cardiac function: a systematic review and meta-analysis

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