Weight Loss and Exercise Walking Reduce Pain and Improve Physical Functioning in Overweight Postmenopausal Women with Knee Osteoarthritis

Martin, Kelly E.; Fontaine, Kevin R.; Nicklas, Barbara J.; Dennis, Karen E.; Goldberg, Andrew P.; Hochberg, Marc C.

doi:10.1097/00124743-200108000-00006

Cited by 31 publications

(47 citation statements)

References 17 publications

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“…It contains 17 functional activity items, 5 pain-related items, and 2 stiffness items. The WOMAC is a valid and reliable instrument that has been used widely in a variety of clinical trials involving patients with OA of the knee [9,[11][12][13][14].…”

Section: Western Ontario Macmastermentioning

confidence: 99%

Relationship between depression and functional measures in overweight and obese persons with osteoarthritis of the knee

Possley

Budiman‐Mak

O’Çonnell³

et al. 2009

JRRD

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Abstract-Depression is common in overweight and obese individuals with chronic illness. The purpose of this study was to determine the relationship between depression and functional status. Baseline data were used from 105 overweight/obese participants who enrolled in a clinical trial for overweight and obese adults with osteoarthritis of the knee. Forty-two percent of the sample was classified as depressed according to the Center for Epidemiologic Studies Depression Scale. A moderate relationship was seen between perceived physical function and physical performance in patients who were not depressed that did not exist in patients reporting depressive symptoms. In a stepwise regression analysis, poorer function (as measured by the Western Ontario and MacMaster Universities (Osteoarthritis Index) function subscale) and younger age accounted for 29 percent of the variance in depressive symptoms.

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Section: Western Ontario Macmastermentioning

confidence: 99%

Relationship between depression and functional measures in overweight and obese persons with osteoarthritis of the knee

Possley

Budiman‐Mak

O’Çonnell³

et al. 2009

JRRD

View full text Add to dashboard Cite

show abstract

“…12 It also reduces the symptoms and/or improves the clinical findings in several obesityrelated chronic conditions, such as diabetes, 12 coronary heart disease, 13 asthma, 14,15 obstructive sleep apnoea, [16][17][18] and osteoarthrosis. 19,20 The marked weight loss achieved by surgical techniques has been associated with clear long-term improvements in HRQL. [21][22][23][24][25][26][27] The previous weight loss studies with lifestyle intervention have shown various improvements in HRQL, but the studies have usually been very short in duration.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in obese outpatients losing weight with very-low-energy diet and behaviour modification: a 2-y follow-up study

et al. 2003

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OBJECTIVE:To study health-related quality of life (HRQL) in a clinically selected sample obese outpatients. DESIGN: A single-strand before and after study with 2-y follow-up after treatment comprising 10 weeks on very-low-energy diet (VLED) and 4 months of behaviour modification in groups. SUBJECTS: A total of 126 patients (mean (s.d.) age 48.2 (11.1) y and body mass index (BMI) 42.8 (6.2) kg/m 2 (63% women)) referred for treatment in an obesity clinic. MEASUREMENTS: Weight and HRQL using questionnaires (RAND 36-Item Health Survey 1.0 and Obesity-related Psychosocial problems-scale). RESULTS: In all, 100 patients (61% women) completed the treatment and 67 (71% women) completed the 2-y follow-up. The mean (s.d.) weight loss was 12.5 (5.6)% at the end of group therapy, 6.0 (7.1)% at 1 y, and 2.6 (7.5)% at 2 y. At baseline, the mean (s.d.) score for OP-scale was 61.9 (24.6). The mean scores on every RAND-36 scale were markedly lower than in the Finns without chronic conditions. All the scales in HRQL improved markedly during the treatment. During the follow-up, all the scales started to return back towards baseline levels and at 2 y, only obesity-related psychosocial problems and physical functioning were still improved relative to baseline. In categories of weight change at 2 y (Z10% weight loss, 0-9.9% weight loss, weight gain), obesity-related psychosocial functioning, physical functioning, and general health showed dose-response improvement with increasing weight loss. A Z10% weight loss at 2 y after treatment was associated with clear improvement in obesity-related psychosocial problems, physical functioning, physical role functioning, bodily pain, general health, mental health, and vitality. A 0-9.9% weight loss was associated with improvement in obesity-related psychosocial problems and physical functioning. Weight gain was associated with improvement in obesity-related psychosocial problems and social functioning. The study population was too small to examine possible gender differences. CONCLUSIONS: Treatment with VLED and behaviour modification produces marked short-term weight loss and clear improvement in all aspects of HRQL. At 2 y after treatment, the average maintained weight loss is modest. However, one-third of patients maintain Z5% weight loss. Improvement in obesity-related psychosocial problems and physical functioning is associated even with o10% of maintained weight loss. Since the pattern of HRQL changes did only partly follow the pattern of weight change as expected, other factors, such as the therapeutic effect of participating in the weight loss programme or increase in physical activity, may affect HRQL responses.

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“…12 It also reduces the symptoms and/or improves the clinical findings in several obesity-related chronic conditions, such as diabetes, 12 coronary heart disease, 13 asthma, 14,15 obstructive sleep apnoea, [16][17][18] and osteoarthrosis. 19,20 The marked weight loss achieved by surgical techniques has been associated with clear long-term improvements in HRQL. [21][22][23][24][25][26][27] The previous weight loss studies with lifestyle intervention have shown various improvements in HRQL, but the studies have usually been very short in duration.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in obese outpatients losing weight with very-low-energy diet and behaviour modification—a 2-y follow-up study

et al. 2003

View full text Add to dashboard Cite

OBJECTIVE:To study health-related quality of life (HRQL) in a clinically selected sample of obese outpatients. DESIGN: A single-strand before and after study with 2-y follow-up after treatment comprising 10 weeks on very-low-energy diet (VLED) and 4 months of behaviour modification in groups. SUBJECTS: A total of 126 (mean (s.d.) age 48.2 (11.1) y and body mass index 42.8 (6.2) kg/m 2 obese patients (63% women) referred for treatment in an obesity clinic. MEASUREMENTS: Weight and HRQL using questionnaires (RAND 36-Item Health Survey 1.0 and Obesity-related Psychosocial problems scale (OP-scale)). RESULTS: A total of 100 patients (61% women) completed the treatment and 67 (71% women) completed the 2-y follow-up. The mean (s.d.) weight loss was 12.5 (5.6)% at the end of group therapy, 6.0 (7.1)% at 1 y, and 2.6 (7.5)% at 2 y. At baseline, the mean (s.d.) score for the OP-scale was 61.9 (24.6). The mean scores on every RAND-36 scale were markedly lower than in the Finns without chronic conditions. All the scales in HRQL improved markedly during the treatment. During the follow-up, all the scales started to return towards baseline levels, and at 2 y only obesity-related psychosocial problems and physical functioning were still improved relative to baseline. In categories of weight change at 2 y (Z10% weight loss, 0-9.9% weight loss, weight gain), obesity-related psychosocial functioning, physical functioning, and general health showed dose-response improvement with increasing weight loss. A Z10% weight loss at 2 y after treatment was associated with clear improvement in obesity-related psychosocial problems, physical functioning, physical role functioning, bodily pain, general health, mental health, and vitality. A 0-9.9% weight loss was associated with improvement in obesity-related psychosocial problems and physical functioning. Weight gain was associated with improvement in obesity-related psychosocial problems and social functioning. The study population was too small to examine possible gender differences. CONCLUSIONS: Treatment with VLED and behaviour modification produces marked short-term weight loss and clear improvement in all aspects of HRQL. At 2 y after treatment, the average maintained weight loss is modest. However, 1/3 of patients maintained a Z5% weight loss. Improvement in obesity-related psychosocial problems and physical functioning is associated even with less than 10% of maintained weight loss. Since the pattern of HRQL changes only partly followed the pattern of weight change as expected, other factors, such as the therapeutic effect of participating in the weight loss programme or increase in physical activity, may affect HRQL responses.

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Weight Loss and Exercise Walking Reduce Pain and Improve Physical Functioning in Overweight Postmenopausal Women with Knee Osteoarthritis

Cited by 31 publications

References 17 publications

Relationship between depression and functional measures in overweight and obese persons with osteoarthritis of the knee

Relationship between depression and functional measures in overweight and obese persons with osteoarthritis of the knee

Health-related quality of life in obese outpatients losing weight with very-low-energy diet and behaviour modification: a 2-y follow-up study

Health-related quality of life in obese outpatients losing weight with very-low-energy diet and behaviour modification—a 2-y follow-up study

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