Weight Loss and/or Hypernatraemia in Inadequately Breastfed Term Neonates having Non-haemolytic Unconjugated Hyperbilirubinaemia

Singla, Monika; Malik, Sushma; Korday, Charusheela Sujit; Paldiwal, Ashutosh Abhimanyu

doi:10.7860/jcdr/2018/31791.11066

Cited by 2 publications

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“…A total of 678 records underwent title and abstract screening after duplicates were removed. A total of 30 records were considered for full-text screening, and 18 were excluded for the following reasons: non-primary research ( n = 2) [ 14 , 15 ], wrong patient population ( n = 5, where the studies focused on neonates with physiological jaundice or with congenital anomalies) [ 16 , 17 , 18 , 19 , 20 ], wrong study type ( n = 3, either case report or in vitro/animal studies) [ 21 , 22 , 23 ], and wrong study design ( n = 8, assessed wrong exposure, incorrect comparison groups or lack of formal comparison) [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review

et al. 2023

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Breast milk is tailored for optimal growth in all infants; however, in some infants, it is related to a unique phenomenon referred to as breast milk jaundice (BMJ). BMJ is a type of prolonged unconjugated hyperbilirubinemia that is often late onset in otherwise healthy-appearing newborns, and its occurrence might be related to breast milk itself. This review aims to systematically evaluate evidence regarding breast milk composition and the development of BMJ in healthy neonates. PubMed, Scopus and Embase were searched up to 13 February 2023 with key search terms, including neonates, hyperbilirubinemia, and breastfeeding. A total of 678 unique studies were identified and 12 were ultimately included in the systematic review with narrative synthesis. These included studies covered both nutritional compositions (e.g., fats and proteins) and bioactive factors (e.g., enzymes and growth factors) of breast milk and formally assessed the difference in the concentration (or presence) of various endogenous components of breast milk collected from mothers of BMJ infants and healthy infants. The results were inconsistent and inconclusive for most of the substances of interest, and there was only a single study available (e.g., total energy and mineral content, bile salts and cytokines); conflicting or even contradictory results arose when there were two or more studies on the subject matter (e.g., fats and free fatty acids contents and epidermal growth factor). The etiology of BMJ is likely multifactorial, and no single constituent of breast milk could explain all the BMJ cases observed. Further well-designed studies are warranted to investigate the complex interaction between maternal physiology, the breast milk system and infant physiology before this field could be progressed to uncover the etiology of BMJ.

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Section: Resultsmentioning

confidence: 99%

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review

et al. 2023

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“…In contrast, a lower correction rate is associated with prolonged high sodium levels, higher mortality, and complications (10). A correction rate of 0.5 mmol/L per hour is desirable to avoid adverse outcomes (6,9). Adjusting fluid and sodium infusion is essential for the appropriate correction rate of serum sodium levels (9).…”

Section: Discussionmentioning

confidence: 99%

“…A correction rate of 0.5 mmol/L per hour is desirable to avoid adverse outcomes (6,9). Adjusting fluid and sodium infusion is essential for the appropriate correction rate of serum sodium levels (9). A systematic review discussed that the treatment of hypernatremia neonates differs based on the amount of dehydration and renal concentration (13).…”

Section: Discussionmentioning

confidence: 99%

Management of Hypernatremia Dehydration in Three Neonates with Ichthyosis

2023

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Introduction: Ichthyosis is an epidermal disruption that increases insensible water loss. Hypernatremic dehydration is a consequence of skin disruption. This study reviewed the treatment of hypernatremic dehydration in patients with ichthyosis comparing to patients with intact skin. Case Presentation: We studied five neonates with hypernatremia, including three ichthyosis cases and two normal-skin neonates. This case-series study showed that the sodium correction rate is slower in infants with ichthyosis than in infants with normal skin. The first and second neonates needed less sodium than fluid intake than normal skin infants, although fluid requirement was lower in the third ichthyosis infant than in others due to less skin disruption in this infant. Conclusions: Fluid therapy in hypernatremic dehydration in ichthyosis patients is different from neonates with intact skin because of excessive insensible water loss in these patients. It may be needed to give more fluid and less sodium depending on the degree of skin disruption, which may not be determined by physical examination.

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Weight Loss and/or Hypernatraemia in Inadequately Breastfed Term Neonates having Non-haemolytic Unconjugated Hyperbilirubinaemia

Cited by 2 publications

References 0 publications

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review

Management of Hypernatremia Dehydration in Three Neonates with Ichthyosis

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