Weight Loss as a Predictor of Survival and Disease Progression in HIV Infection

Wheeler, David A.; Gibert, Cynthia L.; Launer, Cynthia A.; Muurahainen, Norma; Elion, Richard; Abrams, Donald I.; Bartsch, Glenn E.

doi:10.1097/00042560-199805010-00012

Cited by 214 publications

(136 citation statements)

References 13 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…17 A study reported that as little as 5% of weight loss over 4 months was associated with decreased survival. 20 We also found that the majority of the patients lived with family .i.e. the major bulk of HIV infected patients had good support from the family as 61.7% lived with their family.…”

Section: Discussionmentioning

confidence: 57%

Prevalence and CD4 Cell Count Pattern of TB Co-infection Among HIV Infected Individuals In Nepal

Niraula

Barnawal

Agrahari

et al. 2013

SAARC J. Tuber. Lung Dis. HIV/AIDS

View full text Add to dashboard Cite

Background: Mycobacterium tuberculosis (TB) and Human Immunodefi ciency Virus (HIV) infections are two major public health problems in many parts of the world, particularly in developing counties like Nepal. The objective of the study is to fi nd out prevalence and clinical presentation of the TB co-infection among HIV infected individuals and pattern of CD4 cell count in relation to types of TB and response of ART.

show abstract

Section: Discussionmentioning

confidence: 57%

Prevalence and CD4 Cell Count Pattern of TB Co-infection Among HIV Infected Individuals In Nepal

Niraula

Barnawal

Agrahari

et al. 2013

SAARC J. Tuber. Lung Dis. HIV/AIDS

View full text Add to dashboard Cite

show abstract

“…Such an impact of nutritional state on survival was elegantly shown by Suttmann et al (1995), who demonstrated an independent effect of loss of body cell mass on survival. More recently, the Community Programs for Clinical Research in AIDS have demonstrated that a weight-losing trend predicts subsequent mortality and susceptibility to opportunistic infections (Wheeler et al 1998). Thus, there does appear to be evidence that impaired nutritional state adversely influences disease progression.…”

Section: Nutrition and Human Immunodeficiency Virus Disease Progressionmentioning

confidence: 99%

Nutrition and immune function in human immunodeficiency virus infection

Macallan

1999

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The triad of human immunodeficiency virus (HIV) infection, nutritional status and immune function are intimately related, each factor having effects on the others. The dominant effect in this three-way relationship is the effect of HIV infection on nutritional status, an effect which, until the advent of potent anti-retroviral drugs, has been manifest primarily as wasting. Recently, more complex metabolic abnormalities have become apparent, particularly fat redistribution syndromes, hyperlipidaemia and hypercholesterolaemia. For the converse effect, the effect of nutritional state on HIV disease progression, there is good evidence that clinical outcome is poorer in individuals with compromised nutrition. However, the beneficial effects of nutritional support have been more difficult to demonstrate. For macronutrients, effective macronutrient supply improves survival in severely-malnourished individuals and may have beneficial effects in less-severely-affected individuals. Micronutrient deficiencies appear to be involved in modifying clinical HIV disease and may also be associated with enhanced mother-to-child transmission of virus, particularly in developing countries. Intervention trials in this setting are currently under way. In conclusion, the interaction of HIV infection and nutrition is of great importance not just because of the major impact that HIV infection has on nutritional state, but also because strategies to improve nutritional status, both quantitatively and qualitatively, may have a beneficial effect on the clinical and immunological course of the disease.

show abstract

“…Limited access to food is associated with worse antiretroviral therapy (ART) adherence. 14,16,17 In addition, HIVinfected patients' nutritional status or body mass, which has been associated with worse immunologic and virologic response among HIV-infected individuals, 18,19 is associated with limited access to food. To our knowledge, no large or multisite study has been conducted in the U.S. examining the association between food insecurity and HIV outcomes, or examining ART adherence and body mass index (BMI) as plausible mediators of the observed associations.…”

Section: Introductionmentioning

confidence: 99%