“…[33][34][35][36] Meanwhile, interventions that achieve a sustainable weight loss in the range of 7% to 10% of initial body weight are known to cause significant reduction in the cardiometabolic risks and obesity-associated conditions, including T2D, hyperlipidemia, and hypertension, and hard outcomes such as stroke, myocardial infarction, and death. 22,32 Thus, lowering excess weight in obese patients has major beneficial outcomes, including improving quality of life and cost reductions. In this regard, nonrandomized studies of obese patients treated with fenfluramine/mazindol, fenfluramine/phentermine, caffeine/ephedrine, or mazindol for weight loss reported that the pharmaceutical cost savings arising from a reduced need for medications to treat diabetes, dyslipidemia, and hypertension because of weight loss more than offset the cost of the weight-loss medications.…”