Weight loss for overweight patients with knee or hip osteoarthritis

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the benefits and harms associated with weight loss in overweight individuals with knee or hip osteoarthritis in terms of pain, physical function, quality of life, and safety. Further we will have an explicit focus on quality of the weight loss intervention (including magnitude and intensity) (Herbert 2005), to see whether there is a dose-response relationship at the trial (i.e. group) level. B A C K G R O U N D Description of the condition Osteoarthritis (OA) is a chronic disease characterized by joint pain, tenderness, limitation of movement, crepitus, occasional effusion, and variable degrees of local inflammation, but without systemic effects (Brandt 1986). The aetiology of OA is multi-factorial and includes both generalised constitutional factors (e.g. aging, gender and heredity) and local adverse mechanical factors (e.g. trauma and occupational usage) (Dieppe 2005; Felson 2000). Overweight is an important factor in OA since overload to the affected joint 1 Weight loss for overweight patients with knee or hip osteoarthritis (Protocol)

The influence of the choice of preemptive analgesia on long‐term postsurgical pain after tibial plateau leveling osteotomy in dogs

“…In contrast to previous reports, 1,2 we found a negative correlation between weight and HCPI score both at 6‐month and long‐term follow‐up, providing evidence for a worse outcome for heavier dogs. In man, weight overload and muscle atrophy (which progresses with age) increases the pressure on joints, 33 thereby inducing microtrauma and, in turn, accelerating osteoarthritis development 34 . This may also explain the correlation between HCPI score and weight found in this study.…”

“…In man, weight overload and muscle atrophy (which progresses with age) increases the pressure on joints, 33 thereby inducing microtrauma and, in turn, accelerating osteoarthritis development. 34 This may also explain the correlation between HCPI score and weight found in this study. Also, smaller, lighter dogs can be easily picked up and carried, so their inability to walk, run, or jump is easily overlooked compared with larger breeds.…”