Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults

Mohorko, Nina; Černelič-Bizjak, Maša; Poklar-Vatovec, Tamara; Grom, Gašper; Kenig, Saša; Petelin, Ana; Jenko-Pražnikar, Zala

doi:10.1016/j.nutres.2018.11.007

Cited by 119 publications

(99 citation statements)

References 51 publications

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“…However, the molecular mechanism underlying the cause-and-effect relationship between hypoadiponectinemia and insulin resistance is not yet fully clear [32]. Indeed, in vivo and in vitro studies suggested that adiponectin has an antidiabetic and hypoglycemic effect [33], activating hepatic insulin receptor and promoting pancreatic beta-cell function [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States

Monda

Polito

Lovino

et al. 2020

IJMS

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Adipose tissue is a multifunctional organ involved in many physiological and metabolic processes through the production of adipokines and, in particular, adiponectin. Caloric restriction is one of the most important strategies against obesity today. The very low-calorie ketogenic diet (VLCKD) represents a type of caloric restriction with very or extremely low daily food energy consumption. This study aimed to investigate the physiological effects of a VLCKD on anthropometric and biochemical parameters such as adiponectin levels, as well as analyzing oligomeric profiles and cytokine serum levels in obese subjects before and after a VLCKD. Twenty obese subjects were enrolled. At baseline and after eight weeks of intervention, anthropometric and biochemical parameters, such as adiponectin levels, were recorded. Our findings showed a significant change in the anthropometric and biochemical parameters of these obese subjects before and after a VLCKD. We found a negative correlation between adiponectin and lipid profile, visceral adipose tissue (VAT), C-reactive protein (CRP), and pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), which confirmed the important involvement of adiponectin in metabolic and inflammatory diseases. We demonstrated the beneficial short-term effects of a VLCKD not only in the treatment of obesity but also in the establishment of obesity-correlated diseases.

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Section: Discussionmentioning

confidence: 99%

Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States

Monda

Polito

Lovino

et al. 2020

IJMS

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“…The aim of this diet is to enter a state of nutritional ketosis, deriving energy from fat burn-down, in the form of ketones. Short-term benefits have been postulated by faster weight loss, improved cognitive functioning, appetite suppression, and improved eating behaviour and metabolic profile [2]. However, the long-term benefits have been largely unexplored [5].…”

Section: Discussionmentioning

confidence: 99%

“…A keto diet is a strict low-carbohydrate and high-fat diet. It has recently been very famous in the United States and globally due to its fast weight loss benefits [1,2]. The reduction in carbohydrates enables the body to rely on fat as a predominant energy source leading to a state of ketosis.…”

Section: Introductionmentioning

confidence: 99%

Euglycemic Diabetic Ketoacidosis Precipitated by a Keto Diet: Importance of Dietary History in Diagnosis

Shaikh

Mohamed

Mujeeb

et al. 2020

Cureus

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Diabetic ketoacidosis (DKA) is one of the serious complications of diabetes, especially type 1. It is defined by the triad of hyperglycemia (>250 mg/dL [>13.9 mmol/L]), high anion-gap metabolic acidosis, and increased plasma ketones. Euglycemic ketoacidosis is characterized by DKA without hyperglycemia. We present a rare case of a 28-year-old type 1 diabetic male, presenting with abdominal pain, fatigue, and dizziness after one week of starting a keto diet. He was diagnosed with euglycemic DKA, managed with DKA protocol and given detailed dietary counselling to avoid the keto diet in future.

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“…In addition, a relation between plasmatic BDNF increase and appetite decrease have also been reported. 33…”

Section: Weight and Glycemia Controlmentioning

confidence: 99%

<p>Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats</p>

Ribeiro

Nascimento

Agostinho

et al. 2020

DMSO

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Background: Diabetes mellitus is a syndrome with multiple etiologies involving insulin, in which there is a lack of production and/or loss of sensitivity to this hormone resulting in insulin resistance. Treatment and control of this disease requires changes in diet, use of medication, and lifestyle, such as physical activity. These modifications may compromise quality-of-life if there is no proper guidance for the treatment or alert to possible complications caused by the disease. Methods: This study aimed to evaluate biochemical and hematological parameters, and to assess brain derived neurotrophic factor levels in diabetic Wistar rats submitted to chronic physical exercise. Results: The results demonstrated an increase in plasma concentration of brain-derived neurotrophic factor (BDNF) in association with hyperglycemia reduction in diabetic animals. Discussion: The results obtained suggest that there is a regulation of glucose homeostasis between peripheral tissues and the central nervous system. Exercise-induced BDNF also improved levels of glycemia, body weight, and dyslipidemia. In hematological evaluation, BDNF increase was positively correlated with an improvement in leukocyte parameters. Electrophoresis analyses demonstrated a reduction in levels of pro-inflammatory proteins, lipoprotein fractions, and albumin preservation in diabetic animals trained with elevated concentration of plasma BDNF. Conclusion: In conclusion, this study demonstrated that chronic exercise was able to elevate BDNF levels in plasma, which resulted directly in positive hypoglycemic activity in diabetic animals and a reduction of the metabolic syndrome associated with diabetes mellitus.

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Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults

Cited by 119 publications

References 51 publications

Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States

Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States

Euglycemic Diabetic Ketoacidosis Precipitated by a Keto Diet: Importance of Dietary History in Diagnosis

<p>Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats</p>

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