Weight loss in Alzheimer disease

Gillette-Guyonnet, Sophie; Nourhashémi, F.; Andrieu, Sandrine; Glisezinski, Isabelle de; Ousset, Pierre‐Jean; Rivière, D.; Albarède, J. L.; Vellas, Bruno

doi:10.1093/ajcn/71.2.637s

Cited by 221 publications

(177 citation statements)

References 39 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Nearly half of the GLD residents had a BMI 23. According to the NuSc more than half were classified as malnourished or being at risk for PEM, a finding in line with several previous reports (Sandman et al, 1987;Burns et al, 1989;Carver & Dobson, 1995;Gillette-Guyonnet et al, 2000).…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, more sensitive instruments may have had been able to register the small signs of improvement that were noted by relatives and personnel. Previous studies have shown a decrease of about 3 points in MMSE per year in people with AD (Corey-Bloom et al, 1993;Gillette-Guyonnet et al, 2000). The decrease in MMSE in GLD-I may reflect this expected deterioration.…”

Section: Discussionmentioning

confidence: 79%

“…Chronic disease is often associated with protein-energy malnutrition (PEM) (Cederholm et al, 1993;Pennington, 1998). Certain groups, such as people with dementia, especially Alzheimer's disease (AD) have been identified to be at particularly high risk for PEM (Elmståhl & Steen, 1987;Burns et al, 1989;Wolf-Klein et al, 1995;Carver & Dobson, 1995;CroninStubbs et al, 1997;Wang et al, 1997;Gillette-Guyonnet et al, 2000). It is still not resolved whether the weight loss in demented patients is due to inadequate dietary intake, increased energy expenditure or dementia-related metabolic disturbances (Sandman et al, 1987;Singh et al, 1988;Donaldson et al, 1996;Grundman et al, 1996;Barrett-Connor et al, 1996;Poehlman et al, 1997, Poehlman & Dvorak, 2000.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Faxén‐Irving¹,

Andrén-Olsson²,

Geijerstam³

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

Objectives: We studied the nutritional status and the effects of nutritional intervention on body weight, cognition and activities of daily life (ADL)-function in demented individuals. Design: Controlled non-randomised study. Setting: Group-living for demented elderly (GLD), ie community assisted housing. Subjects and interventions: Twenty-two residents living in one of two units (GLD-I), received oral liquid supplements (1720 kJ=410 kcal=day) and the personnel of the GLD-I were given nutritional education. Fourteen residents in the other unit (GLD-C) served as controls. After 6 months 21 (83 (4) y, 81% women) and 12 (85 (4) y, 100% women) of the participants, respectively, were re-examined according to body mass index (BMI, kg=m 2 ), cognitive function (Mini Mental State Examination (MMSE, 0 -30 p) and Clinical Dementia Rating Scale (CDR) and the Katz' ADL index. Results: Body mass index (BMI) 20 was found in 19% of the participants and 44% had BMI 23. BMI correlated with MMSE (r ¼ 0.43, P < 0.01). The weight of the residents in the intervention group increased by 3.4 (3) kg (P ¼ 0.001) at follow-up, whereas the weight remained unchanged in the control group. The cognitive function was low at the start in both groups, ie MMSE 9 and no apparent positive effect of the nutritional intervention was seen. In addition, the ADL functions appeared to deteriorate in both groups. Conclusions: Being underweight was common among demented elderly in group-living and was related to low cognitive capacity. Five months of oral supplementation, along with education of personnel, was followed by a weight gain. In this study the nutritional treatment did not affect the rate of decline in cognitive function or Katz' ADL index. Sponsorship: Supported by grants from the Swedish National Board of Health and Social Welfare. Semper Foods AB provided the liquid supplements.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Faxén‐Irving¹,

Andrén-Olsson²,

Geijerstam³

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…A BMI <22 kg/m 2 has been used to screen for undernutrition in older patients and is associated with several chronic conditions, including dementia [26]. Patients in this category in the present sample were six times more likely to access health services for hypoglycaemia than those with greater BMI.…”

Section: Discussionmentioning

confidence: 68%

Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study

et al. 2009

View full text Add to dashboard Cite

Aims/hypothesis The aim was to investigate the relationship between severe hypoglycaemia and cognitive impairment in older patients with diabetes. Methods A sample of 302 diabetic patients aged ≥70 years was assessed for dementia or cognitive impairment without dementia in 2001-2002 and a subsample of non-demented patients (n=205) was followed to assess cognitive decline. A history of severe hypoglycaemia was determined from self-reports, physician assessments and records of health service use for hypoglycaemia (HSH). Prospective HSH was determined up to 2006. Data analysis, including multiple logistic and Cox regression models, was used to determine whether: (1) there were cross-sectional associations between hypoglycaemia and cognitive status, (2) historical hypoglycaemia predicted cognitive decline, and (3) baseline cognitive status predicted subsequent HSH.Results There were significant cross-sectional associations between both cognitive impairment and dementia and hypoglycaemia. Independent risk factors for future HSH included dementia (hazard ratio 3.00, 95% CI 1.06-8.48) and inability to self-manage medications (hazard ratio 4.17, 95% CI 1.43-12.13). However, there were no significant associations between historical hypoglycaemia, incident HSH and cognitive decline. Conclusions/interpretation Dementia is an important risk factor for hypoglycaemia requiring health service utilisation. We found no evidence that hypoglycaemia contributes to cognitive impairment in older patients with diabetes.

show abstract

“…Weight loss is a frequent complication of AD and occurs in 30-40% of patients at all stages [2]. It is associated with faster progression of dementia and with nursing home placement [3].…”

mentioning

confidence: 99%

Weight loss as a predictor of dementia and Alzheimer’s disease?

Nourhashémi

Vellas²

2008

Expert Review of Neurotherapeutics

Self Cite

View full text Add to dashboard Cite

Weight loss in Alzheimer disease

Abstract: Nutritional education programs for the caregivers of AD patients seem to be the best way to prevent weight loss and improve the nutritional status of these patients.

Cited by 221 publications

References 39 publications

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study

Weight loss as a predictor of dementia and Alzheimer’s disease?

Contact Info

Product

Resources

About