Weight loss induced by 6‐month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents

Huang, Fengyang; Del-Río-Navarro, Blanca E.; Castro, Gizele; Alcántara, Saúl Torres; Monge, Juan José Luis Sienra; Ontiveros, José Alfredo Pérez; Navarro-Olivos, Efraín; Barron, M.; Lopez, Adar; Villafaña, Santiago; Hong, Enrique

doi:10.1111/j.1365-2214.2010.01173.x

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…26 Roberts et al 12 reported significant reductions in sE-Selectin following an intensive 2-week diet and exercise intervention in overweight youth. In a 6-month lifestyle intervention consisting of once-weekly physical activity and family-focused behavioral and lifestyle modification sessions, Huang and colleagues 27 reported significant reductions in sE-Selectin. However, the observed improvements in sE-Selectin were only noted in participants who exhibited decreases in BMI, whereas participants who remained BMI stable did not decrease sE-Selectin.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneous Vascular Responses to Lifestyle Intervention in Obese Latino Adolescents

Ryder

Vega‐López

Gaesser

et al. 2014

Metabolic Syndrome and Related Disorders

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AbstarctBackground/Objectives: Among adolescents, obesity may increase the risk for premature cardiovascular disease (CVD). Lifestyle interventions may prevent or delay the onset of CVD through improvements in vascular health. The purpose of this study was to examine the effects of a 12-week lifestyle intervention on markers of vascular health in obese Latino youth. Subjects/Methods: Fifteen obese Latino adolescents [body mass index (BMI) percentile = 96.3 -1.1%, 15.0 -1.0 year, 8 females and 7 males] participated in a 12-week lifestyle intervention consisting of nutrition education and physical activity. Markers of vascular health included oxidized low-density lipoprotein (oxLDL), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble endothelial leukocyte adhesion molecule-1 (sE-Selectin).Results: Relative to baseline data, the intervention resulted in lower oxLDL ( -21.8%, P = 0.001) and sESelectin ( -13.3%, P = 0.008) concentrations; sICAM-1 and sVCAM-1 did not change significantly. When examining overall responsiveness to change for each marker, oxLDL was reduced in 93.3%, sE-Selectin was reduced in 78.6%, and sICAM-1 was reduced in 71.4% of participants, respectively, whereas sVCAM-1 was reduced in only 42.9% of participants following lifestyle. Using a composite change score (summed change in four markers) for each participant there was an improvement in at least three of four markers among 64% of participants; this was confirmed by principal component analysis. Conclusions: Therefore, although improvements in the vascular health of obese youth were observed, the vascular response to lifestyle intervention may be heterogeneous. Further investigation into the mechanisms mediating the heterogeneity in vascular response to lifestyle intervention is warranted.

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Section: Discussionmentioning

confidence: 99%

Heterogeneous Vascular Responses to Lifestyle Intervention in Obese Latino Adolescents

Ryder

Vega‐López

Gaesser

et al. 2014

Metabolic Syndrome and Related Disorders

View full text Add to dashboard Cite

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“…56 Huang et al noted improvements in adhesion molecules (selectin E) and fibrinolysis parameters (plasminogen activator inhibitor-1) in participants who showed reduction in BMI z score after a 6-month lifestyle intervention, together with improved triglycerides and glucose homeostasis. 57 These trials primarily focused on exercise interventions, with improved endothelial function, albeit not often to normal when control subjects were included, and some improvement in CIMT in longer studies. These improvements were achieved with concomitant improvements in cardiometabolic risk factors, adiposity and biomarkers, but without normalization of adiposity.…”

Section: Response To Interventionmentioning

confidence: 99%

Cardiovascular Consequences of Childhood Obesity

McCrindle

2015

Canadian Journal of Cardiology

128

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“…Meal replacements are anything we can consume that is already proportioned and ready to eat -and we can eat the whole thing, often packed with extra protein and fiber for greater satiety. Meal replacements are characterized by liquid formulas, powder Keywords: Obesity, Meal Replacement, Weight Reduction formulations reconstituted with water or milk, or nutrition bars that are typically fortified with vitamins and minerals and with or without fiber [4]. Consumption of high fiber starchy foods, mainly whole wheat flour and brown rice has gone down considerably and has been replaced by low fiber refined wheat flour and polished rice [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Meal Replacement and Nutrition Education on Obese Adolescent Girls

Anbuselvi

Kalpana

2014

FoodSci: Indian Journal of Research in Foods and Nutrition

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Obesity has reached epidemic proportions in India in the 21 st century, with morbidity obesity affecting five percent of the country's population. Adolescent is a crucial period in life and implies multiple physiological and psychological changes that affect nutritional needs and habits. Meal skipping and eating irregularly are common during adolescence and especially prevalent during middle and late adolescence. High fiber diets provide bulk or more satiating and have been linked to lower body weight. Nutrition education must help teens to become informed decision makers about their diets. Three hundred adolescent girls were involved in screening for obesity. From them forty five adolescents and baseline survey was conducted with them and then they divided into three groups each have 15 members. In this study they researcher has developed high fiber recipes like kozhukattai, roti and porridge using fiber rich ingredients like varagu, horse gram and curry leaves. Four different samples of high fiber recipes were developed using the same ingredients at various proportion and then it was subjected to organoleptic evaluation with 30 semi-trained panel members. Sample III got over all acceptability then other samples in three high fiber recipes. Recipes are subjected to biochemical analysis. Dietary fiber content in kozhukatti, roti and porridge found to be 7g, 8g and 8g respectively. Power point was prepared for nutrition education based on management of obesity and meal replacement given to obese adolescent girls in group I and nutrition education only nutrition education given to group II. After three months of meal replacement and nutrition education, the changes in height, weight, BMI, Waist to hip ratio and body fat percentage were evaluated. From the study results meal replacement was very effective in weight reduction.

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Weight loss induced by 6‐month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents

Abstract: The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6-month lifestyle intervention.

Cited by 21 publications

References 37 publications

Heterogeneous Vascular Responses to Lifestyle Intervention in Obese Latino Adolescents

Heterogeneous Vascular Responses to Lifestyle Intervention in Obese Latino Adolescents

Cardiovascular Consequences of Childhood Obesity

Effect of Meal Replacement and Nutrition Education on Obese Adolescent Girls

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