Weight loss, ion release and initial mechanical properties of a binary calcium phosphate glass fibre/PCL composite

Ahmed, Ifty; Parsons, Andrew J.; Palmer, G.; Knowles, Jonathan C.; Walker, Gavin S.; Rudd, C.D.

doi:10.1016/j.actbio.2008.03.018

Cited by 85 publications

(82 citation statements)

References 25 publications

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“…The stronger interface of ISP composites protected more PGF fibres from contacting PBS, thus less fibre degradation, which correlated well with media uptake profile as less media was absorbed by ISP composites. Ahmed et al [25] investigated the degradation behaviour of a binary calcium phosphatebased glass fibre reinforced PCL composites (Vf = ~6% and ~14%) within deionized water at 37°C for up to 900 hours. They reported similar mass loss profiles that exhibited a linear mass degradation up to 250 hours.…”

Section: Discussionmentioning

confidence: 99%

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Fully bioresorbable composites have been investigated in order to replace metal implant plates used for hard tissue repair. Retention of the composite mechanical properties within a physiological environment has been shown to be significantly affected due to loss of the integrity of the fibre/matrix interface. This study investigated phosphate based glass fibre (PGF) reinforced polycaprolactone (PCL) composites with 20%, 35% and 50% fibre volume fractions (Vf) manufactured via an in-situ polymerisation (ISP) process and a conventional laminate stacking (LS) followed by compression moulding. Reinforcing efficiency between the LS and ISP manufacturing process was compared, and the ISP composites revealed significant improvements in mechanical properties when compared to LS composites. The degradation profiles and mechanical properties were monitored in phosphate buffered saline (PBS) at 37°C for 28 days. ISP composites revealed significantly less media uptake and mass loss (p<0.001) throughout the degradation period. The initial flexural properties of ISP composites were substantially higher (p<0.0001) than those of the LS composites, which showed that the ISP manufacturing process provided a significantly enhanced reinforcement effect than the LS process. During the degradation study, statistically higher flexural property retention profiles were also seen for the ISP composites compared to LS composites. SEM micrographs of fracture surfaces for the LS composites revealed dry fibre bundles and poor fibre dispersion with polymer rich zones, which indicated poor interfacial bonding, distribution and adhesion. In contrast, evenly distributed fibres without dry fibre bundles or polymer rich zones, were clearly observed for the ISP composite samples, which showed that a superior fibre/matrix interface was achieved with highly improved adhesion.

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Section: Discussionmentioning

confidence: 99%

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…Metaphosphate glass fibre polymer composites were shown to give an acidic pH [18,19] upon degradation: Ahmed et al used glasses in the metaphosphate composition range for fabrication of degradable glass fibre-reinforced composites using poly(lactic acid) [19] and poly-ε-caprolactone [18]. Their results showed very fast degradation of the fibres, resulting in pH 4. pH only increased to neutral after the fibres had completely degraded and only the polymer matrix contributed to the pH (at 350 h, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…However, their lower stiffness (poly(lactic acid) (PLA) screws: around 3 GPa [1]) in comparison to bone (17)(18)(19)(20)(21)(22)(23)(24)(25)(26) GPa [2]) may allow too much bone motion for satisfactory healing and reinforcement therefore is essential. Reinforcement by glass fibres is of interest as the fibres maintain stability and mechanical properties during later states of polymer degradation, and anisotropic materials, such as fibre-composites, offer superior strength and stiffness in comparison to isotropic materials.…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of a degradable phosphate glass fibre reinforced polymer composite for internal fracture fixation

Kobayashi

Brauer

Rüssel

2010

Materials Science and Engineering: C

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“…PGs of various compositions have been successfully fiberised via the melt drawn method [2,[11][12][13]. These PGs have been investigated for use as fibrous reinforcement to improve the mechanical properties of resorbable polymers (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Initial studies on PGs mostly focused on binary and ternary glass systems such as P 2 O 5 -CaO [2] and P 2 O 5 -CaO-Na 2 O [3][4][5][6], whereby the phosphate contents were fixed at 45, 50 and 55 mol% and the CaO:Na 2 O ratios were varied. The benefits of utilising PGs for biomedical use can be seen in their compositions, as they contain elements that are present in the body and as such should be biocompatible [7].…”

Section: Introductionmentioning

confidence: 99%

Core/Clad Phosphate Glass Fibres Containing Iron and/or Titanium

Ahmed¹,

Shaharuddin²,

Sharmin³

et al. 2015

Biomedical Glasses

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Phosphate glasses are novel amorphous biomaterials due to their fully resorbable characteristics, with controllable degradation profiles. In this study, phosphate glasses containing titanium and/or iron were identified to exhibit sufficiently matched thermal properties (glass transition temperature, thermal expansion coefficient and viscosity) which enabled successful co-extrusion of glass billets to form a core/clad preform. The cladding composition for the core/clad preforms were also reversed. Fe clad and Ti clad fibres were successfully drawn with an average diameter of between 30~50 µm. The average cladding annular thickness was estimated to be less than 2 µm. Annealed core/clad fibres were degraded in PBS for a period of 27 days. The strength of the Fe clad fibres appeared to increase from 303 ± 73 MPa to 386 ± 45 MPa after nearly 2 weeks in the dissolution medium (phosphate buffered solution) before decreasing by day 27. The strength of the Ti clad fibres revealed an increase from 236 ± 53 MPa to 295 ± 61 MPa when compared at week 3. The tensile modulus measured for both core/clad fibres ranged between 51 GPa to 60 GPa. During the dissolution study, Fe clad fibres showed a peeling mechanism compared to the Ti clad fibres.

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Weight loss, ion release and initial mechanical properties of a binary calcium phosphate glass fibre/PCL composite

Cited by 85 publications

References 25 publications

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Mechanical properties of a degradable phosphate glass fibre reinforced polymer composite for internal fracture fixation

Core/Clad Phosphate Glass Fibres Containing Iron and/or Titanium

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