Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results

Aller, Erik E. J. G.; Larsen, Thomas Meinert; Claus, H.; Lindroos, Anna Karin; Kafatos, Anthony; Pfeiffer, Andreas F. H.; Martínéz, J. Alfredo; Handjieva‐Darlenska, Teodora; Kunešová, Marie; Stender, Steen; Saris, Wim H. M.; Astrup, Arne; Baak, Marleen A. van

doi:10.1038/ijo.2014.52

Cited by 109 publications

(95 citation statements)

References 26 publications

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“…However, it was not statistically different than the other 2 conditions. This outcome replicates our previous finding (7), but both results diverge from past work that found that MRs significantly increase weight loss (3).…”

Section: Discussioncontrasting

confidence: 42%

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Evaluation of meal replacements and a home food environment intervention for long-term weight loss: a randomized controlled trial

Lowe

Butryn

Zhang

2018

The American Journal of Clinical Nutrition

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Background: Lifestyle change treatments for weight loss produce medically meaningful weight reductions, but lost weight is usually regained. Meal replacements (MRs) represent one avenue for improving long-term weight loss. Another, nutrition-focused approach involves having participants make specific changes in the energy density, composition, and structure of the foods in their personal food environments. Objective: Three conditions were compared: behavior therapy (BT), BT plus MRs (BT+MR), and a nutrition-focused treatment aimed at modifying the home food environment (HFE). Design: Overweight and obese individuals (n = 262) were randomly assigned to 1 of the 3 conditions. Treatment occurred in weekly groups for 6 mo and in biweekly groups for 6 mo. Assessments were conducted at baseline and at 6, 12, 18, 24, and 36 mo. Multilevel models were used to estimate weight-change trajectories for each participant and to examine the treatment group effect on long-term weight loss. Results: A multilevel analysis indicated that all 3 groups showed significant weight loss over 12 mo that was gradually regained to the 36-mo follow-up. Mean ± SD percentages of baseline weight loss at 12 mo for BT, BT+MR, and HFE were 9.41% ± 7.92%, 10.37% ± 7.77%, and 10.97% ± 7.79%, respectively. Comparable percentages at 36 mo were 4.21% ± 8.64%, 3.06% ± 6.93%, and 4.49% ± 7.83%. Those in the HFE condition lost more weight than those receiving BT through the 36-mo assessment (P < 0.01), as reflected in 2 treatment × time interactions. Further analyses showed that HFE produced the largest increases in cognitive restraint and that this increase largely mediated the HFE group's improved weight loss. Conclusion:The nutrition-focused intervention studied here produced modestly greater long-term weight loss than BT, an effect that was largely explainable by an unexpected boost in cognitive restraint in this condition. This study was registered at clinicaltrials.gov as NCT01065974.

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Section: Discussioncontrasting

confidence: 42%

“…A second approach focuses on making numerous qualitative and quantitative modifications to nutritional intake. Studies have found support for reducing the energy density (ED) of the diet and manipulating the glycemic index and the protein content of the diet to increase weight loss (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of meal replacements and a home food environment intervention for long-term weight loss: a randomized controlled trial

Lowe

Butryn

Zhang

2018

The American Journal of Clinical Nutrition

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“…Indeed, significant differences in the weight-loss tendency were found by others to be dependent on participant sex in different slimming interventions [45]. Additional findings concerning weight maintenance for longer periods of monitoring after weight loss seem to reinforce the role of protein in the success of managing weight regain [46].…”

Section: Approaches To Dietary Advice and Weight Maintenancementioning

confidence: 89%

The Impact of Gender and Protein Intake on the Success of Weight Maintenance and Associated Cardiovascular Risk Benefits, Independent of the Mode of Food Provision: The DiOGenes Randomized Trial

Navas-Carretero

Holst

Baak

et al. 2015

Journal of the American College of Nutrition

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“…In conclusion, between group comparison of the composition of weight loss and weight gain requires a careful matching for baseline body composition, for example when examining the effect of glycemic load [24] or glycemic index and protein intake [25] on weight regain after diet induced weight loss.…”

Section: Methodological Requirements Ii: Normalizing Changes In Fat Amentioning

confidence: 99%

Measuring the impact of weight cycling on body composition

Bosy‐Westphal

Müller

2014

Current Opinion in Clinical Nutrition and Metabolic Care

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Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results

Abstract: A higher protein content of an ad libitum diet improves weight loss maintenance in overweight and obese adults over 12 months.

Cited by 109 publications

References 26 publications

Evaluation of meal replacements and a home food environment intervention for long-term weight loss: a randomized controlled trial

Evaluation of meal replacements and a home food environment intervention for long-term weight loss: a randomized controlled trial

The Impact of Gender and Protein Intake on the Success of Weight Maintenance and Associated Cardiovascular Risk Benefits, Independent of the Mode of Food Provision: The DiOGenes Randomized Trial

Measuring the impact of weight cycling on body composition

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