Weight reduction ameliorates inflammatory cytokines, adipocytokines and endothelial dysfunction biomarkers among Saudi patients with type 2 diabetes

El-Kader, Shehab M Abd; Al-Jiffri, Osama H; Neamatallah, Ziyad; Alkhateeb, Afnan M.; Alfawaz, Saad S.

doi:10.4314/ahs.v20i3.39

Cited by 12 publications

(19 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complete text of the remaining 29 articles was evaluated, and among them, 14 articles were excluded due to their lack of CG (control group) or CG not engaging in exercise, as well as ambiguous or incomplete data. Therefore, 15 records were included in this study; however, two records [23,24] were the subsequent study of Abd El-Kader, Al-Jiffri [25] and thus, Abd El-Kader, Al-Jiffri [25] was used as the reference record in this review. While Abd El-Kader and Al-Jiffri [24] reported data on leptin and adiponectin, Osama and Shehab [23] reported on lipid pro les.…”

Section: Searchmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review and Meta-Analysis on the Effectiveness of Aerobic Exercise and Diet for Individuals with Type 2 Diabetes and Obesity

AL-Mhanna,

Rocha-Rodriguesc,

Mohamed

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Lifestyle changes involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). However, the effectiveness of combining aerobic exercise and diet (AEDT) in obese T2DM patients has not been studied in a systematic review and meta-analysis. Therefore, the purpose of this review was to systematically evaluate the effects of AEDT on individuals with obesity and T2DM. Methodology: A comprehensive search of the PubMed, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. Statistical analysis was performed using the random effects model for continuous variables, and the results were presented as mean differences (MD) or standardized mean difference (SMD) with 95% confidence intervals (CI). Results Out of the 16,129 studies identified, 15 trials involving a total of 2,454 patients were included in the meta-analysis. The findings revealed significant reductions in body mass index, body weight, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride levels, glycated hemoglobin (HbA1c), fasting blood glucose, fasting plasma insulin, leptin, interleukin-6 (IL-6), and C-reactive protein (CRP) (p < 0.005) compared to the standard treatment (ST) group. On the other hand, there was a significant increase in adiponectin levels in response to AEDT (p < 0.005). However, when evaluating obesity-related factors, no significant differences were observed between the AEDT and ST groups for parameters such as fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and tumor necrosis factor-alpha (TNF-α) (p > 0.05). Conclusions AEDT could be considered an additional therapy in conjunction with conventional clinical treatments due to its significant positive impact on obese T2DM patients. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for reducing the need for aggressive pharmacological approaches in individuals with obesity and T2DM.

show abstract

Section: Searchmentioning

confidence: 99%

“…In the included trials, patients were randomly allocated to intervention and CG. In all 13 trials, the intervention of AEDT [25][26][27][28][29][30][31][32][33][34][35][36][37]. The duration of the interventions in the included trials was varied.…”

Section: The Intervention Characteristicsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis on the Effectiveness of Aerobic Exercise and Diet for Individuals with Type 2 Diabetes and Obesity

AL-Mhanna,

Rocha-Rodriguesc,

Mohamed

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, clinical studies have reported an anti-inflammatory, cardioprotective and slimming effect of PA. For example, a study in obese men showed that exercise was more effective than diet in reducing body weight (BW), improving the systemic inflammatory profile and IR and circulating levels of adipokines ( 204 ). Likewise, a study conducted in obese patients with T2DM subjected to dietary restriction and aerobic exercise reported that after a 3-month intervention, adiponectin levels rose while BMI and TNF-α, IL-6 and leptin levels fell significantly ( 205 ).…”

Section: Non-pharmacological Approach To Adipocyte-myocardiocyte Defective Signaling: Impact Of Lifestylementioning

confidence: 99%

The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium

et al. 2021

View full text Add to dashboard Cite

Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen in the human obese phenotype. These processes promote an abnormal adipocyte proteomic reprogramming, whereby these cells become a source of abnormal signals, affecting vascular and myocardial tissues, leading to meta-inflammation, atrial fibrillation, coronary artery disease, heart hypertrophy, heart failure and myocardial infarction. This review first discusses the pathophysiology and consequences of adipose tissue expansion, particularly their association with meta-inflammation and microbiota dysbiosis. We also explore the precise mechanisms involved in metabolic reprogramming in AT that represent plausible causative factors for CVD. Finally, we clarify how lifestyle changes could promote improvement in myocardiocyte function in the context of changes in AT proteomics and a better gut microbiome profile to develop effective, non-pharmacologic approaches to CVD.

show abstract

“…Saudi scientists 38 describe how “weight reduction ameliorates inflammatory cytokines, adipocytokines and endothelial dysfunction biomarkers among patients with type 2 diabetes.”…”

Section: Now To Diabetes Mellitusmentioning

confidence: 99%

Twenty years of African Health Sciences as infections continue to plague our continent

Tumwine¹

2020

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

Weight reduction ameliorates inflammatory cytokines, adipocytokines and endothelial dysfunction biomarkers among Saudi patients with type 2 diabetes

Cited by 12 publications

References 55 publications

A Systematic Review and Meta-Analysis on the Effectiveness of Aerobic Exercise and Diet for Individuals with Type 2 Diabetes and Obesity

A Systematic Review and Meta-Analysis on the Effectiveness of Aerobic Exercise and Diet for Individuals with Type 2 Diabetes and Obesity

The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium

Twenty years of African Health Sciences as infections continue to plague our continent

Contact Info

Product

Resources

About