Weight regain, but not weight loss exacerbates hepatic fibrosis during multiple weight cycling events in male mice

Chiang, Chun‐Hsien; Zhang, Ting-Rui; Hsu, Pu‐Sheng; Lin, Shau‐Ping; Chen, Ching‐Yi

doi:10.1007/s00394-024-03326-w

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…If the increase in steatosis in the I-WD group might be a consequence of the lipid intake increase during the periods of an LCHFD, several preclinical and clinical studies showed that an LCHFD did not induce hepatic fat accumulation, and had beneficial effects on NAFLD [28,33,42,43]. Moreover, the development of NAFLD induced by weight cycling has already been observed in other studies, which suggest that the increase in the risk of hepatic complications is due to the weight fluctuations [44,45]. The mechanisms behind the link between weight cycling and NAFLD remain unclear but could involve a redistribution of body fat towards visceral adipose tissue, strengthening the risk of metabolic complications, including NAFLD [10].…”

Section: Discussionmentioning

confidence: 89%

Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model

Charlot,

Bringolf,

Debrut

et al. 2024

Nutrients

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Weight cycling is a major challenge in obesity management. Caloric restriction is known to promote this phenomenon, but the impact of macronutrient changes during dieting remains unclear. This study aimed to determine the role of macronutrient changes in weight maintenance without caloric restriction by alternating between two hypercaloric diets: a high-carbohydrate, high-fat Western diet (WD) and a low-carbohydrate, high-fat diet (LCHDF). Obesity was induced in 8-week-old C57BL/6 male mice by 10 weeks of WD feeding. Then, the mice were subjected to 12 weeks of LCHFD interspersed with WD (I-WD), 3 periods of 2-week LCHFD followed by 2 periods of 3-week WD, or 12 weeks of continuous WD (C-WD). C-WD and I-WD mice were compared to standard diet (SD) mice. In the I-WD group, each LCHFD period decreased weight gain, but mice regained weight after WD resumption. I-WD mice exhibited obesity, dyslipidemia, and glucose intolerance, similarly to the C-WD mice. I-WD mice also developed nonalcoholic steatohepatitis, associated with an increase in type-III collagen gene expression and a decrease in FGF21 protein levels, in comparison with SD. I-WD mice developed weight cycling despite maintaining a high caloric consumption, suggesting that changes in macronutrients during dieting are also a trigger of weight regain.

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Section: Discussionmentioning

confidence: 89%

Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model

Charlot,

Bringolf,

Debrut

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish

Hsu,

Chiang,

Liu

et al. 2024

IJMS

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Weight regain within one year after weight loss is frequently observed and is referred to as yo-yo dieting or weight cycling. In this study, we explore the effects of yo-yo dieting on the liver, adipose tissue, and muscle characteristics of male zebrafish. Four-month-old AB wild-type male zebrafish were randomly assigned to three groups: high-calorie intake (H, seven meals per day), low-calorie intake (L, two meals per day), and yo-yo diet (the low- and high-calorie alternation switched every two weeks) groups. Feeding the fish the H diet for over 8 weeks led to steatosis and damage to the liver. The yo-yo diet reduced liver lipid accumulation at week eight but caused a similar degree of lipid accumulation as the H diet thereafter. It was found that twenty weeks of yo-yo dieting actually exacerbated hepatic damage. Compared to the L diet, feeding the fish on the yo-yo and H diets for a period of 20 weeks significantly increased the size of muscle fibers, resulting in higher speed during burst swimming and a significant increase in the size and number of adipocytes in the abdominal tissue. To summarize, short-term yo-yo dieting was found to attenuate hepatosteatosis and maintain fast-twitch muscle function. Long-term yo-yo dieting preserved fast-twitch muscle function and muscle fiber size; however, it exacerbated the pathological changes in the liver.

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Weight regain, but not weight loss exacerbates hepatic fibrosis during multiple weight cycling events in male mice

Cited by 2 publications

References 39 publications

Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model

Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model

Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish

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