First, we present some simple (and easily verifiable) necessary conditions and sufficient conditions for boundedness of the multiplication operator M u and composition operator C T acting from Orlicz space L 1 () into Orlicz space L 2 () over arbitrary complete, σ-finite measure space (, , μ). Next, we investigate the problem of conditions on the generating Young functions, the function u, and/or the function h = d(μ • T −1)/dμ, under which the operators M u and C T are of closed range or finite rank. Finally, we give necessary and sufficient conditions for boundedness of the operators M u and C T in terms of techniques developed within the theory of Musielak-Orlicz spaces.