Weighting evidence in MS: Obesity and neurodegeneration

Costello, Fiona; Petzold, Axel

doi:10.1177/1352458520912171

Cited by 4 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Obesity and metabolic syndrome have been reported to be associated with more rapid neurodegeneration in MS, and although the pathophysiologic basis remains unknown, proinflammatory cytokines are hypothesized to be contributory. 27 There is no known direct association between smoking and ON, but a meta-analysis 28 identified smoking as a significant factor associated with MS onset, and smokers were more likely to develop secondary progressive MS. 29 These potential risk factors will require further prospective evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…No meaningful effect modification was observed by age group or sex among those with recorded data. Obesity and metabolic syndrome have been reported to be associated with more rapid neurodegeneration in MS, and although the pathophysiologic basis remains unknown, proinflammatory cytokines are hypothesized to be contributory . There is no known direct association between smoking and ON, but a meta-analysis identified smoking as a significant factor associated with MS onset, and smokers were more likely to develop secondary progressive MS .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Obesity is directly related to impairment of cognitive function and an increased risk of different forms of dementia. Clinical and experimental evidence indicates that obesity and/or a high-fat diet is associated with impairment of learning, memory, and executive functioning (Anstey et al, 2011;Bremer and Jialal, 2013;Miller and Spencer, 2014;Saltiel and Olefsky, 2017;Costello and Petzold, 2020). Many studies have been carried out on the correlation of BMI-cognitive function and waist circumferencecognitive function.…”

Section: Mets: Obesity Diabetes and Cognitive Functionsmentioning

confidence: 99%

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

Maiuolo

Gliozzi

Musolino

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Metabolic syndrome is not a single pathology, but a constellation of cardiovascular disease risk factors including: central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. The global incidence of Metabolic syndrome is estimated to be about one quarter of the world population; for this reason, it would be desirable to better understand the underlying mechanisms involved in order to develop treatments that can reduce or eliminate the damage caused. The effects of Metabolic syndrome are multiple and wide ranging; some of which have an impact on the central nervous system and cause neurological and neurodegenerative diseases. Autophagy is a catabolic intracellular process, essential for the recycling of cytoplasmic materials and for the degradation of damaged cellular organelle. Therefore, autophagy is primarily a cytoprotective mechanism; even if excessive cellular degradation can be detrimental. To date, it is known that systemic autophagic insufficiency is able to cause metabolic balance deterioration and facilitate the onset of metabolic syndrome. This review aims to highlight the current state of knowledge regarding the connection between metabolic syndrome and the onset of several neurological diseases related to it. Furthermore, since autophagy has been found to be of particular importance in metabolic disorders, the probable involvement of this degradative process is assumed to be responsible for the attenuation of neurological disorders resulting from metabolic syndrome.

show abstract

“…This correlation is thought to be due to ceramide-induced DNA methylation of antiproliferative genes, resulting in decreased expression levels that favor proliferation (Castro et al, 2019). Additionally, other studies have suggested that obesity in MS patients may also be associated with increased rates of retinal neuroaxonal loss, as a marker of neurodegeneration in MS (Costello and Petzold, 2020).…”

Section: Brain Volume Declinementioning

confidence: 99%

The complex relationship between obesity and neurodegenerative diseases: an updated review

Neto,

Fernandes,

Barateiro

2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Obesity is a global epidemic, affecting roughly 30% of the world’s population and predicted to rise. This disease results from genetic, behavioral, societal, and environmental factors, leading to excessive fat accumulation, due to insufficient energy expenditure. The adipose tissue, once seen as a simple storage depot, is now recognized as a complex organ with various functions, including hormone regulation and modulation of metabolism, inflammation, and homeostasis. Obesity is associated with a low-grade inflammatory state and has been linked to neurodegenerative diseases like multiple sclerosis (MS), Alzheimer’s (AD), and Parkinson’s (PD). Mechanistically, reduced adipose expandability leads to hypertrophic adipocytes, triggering inflammation, insulin and leptin resistance, blood-brain barrier disruption, altered brain metabolism, neuronal inflammation, brain atrophy, and cognitive decline. Obesity impacts neurodegenerative disorders through shared underlying mechanisms, underscoring its potential as a modifiable risk factor for these diseases. Nevertheless, further research is needed to fully grasp the intricate connections between obesity and neurodegeneration. Collaborative efforts in this field hold promise for innovative strategies to address this complex relationship and develop effective prevention and treatment methods, which also includes specific diets and physical activities, ultimately improving quality of life and health.

show abstract

Weighting evidence in MS: Obesity and neurodegeneration

Cited by 4 publications

References 11 publications

Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease

Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease

From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

The complex relationship between obesity and neurodegenerative diseases: an updated review

Contact Info

Product

Resources

About