Weil’s disease or acute liver failure? Look in the eyes!

Sama, Sonu; Agarwal, Ankit; Ramakumar, Nirupa; Sogal, P Sachin

doi:10.1007/s00134-019-05764-1

Cited by 1 publication

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“…In addition, it has been reported that different types of Leptospira can and may require liver transplantation (32). The presence of conjunctival icterus, increased creatinine phosphokinase (CPK) levels, and less severe transaminitis suggests the presence of Weil's syndrome, rather than acute liver failure of a different etiology (33). Pulmonary manifestations and a state of shock add to the severity to the clinical syndrome.…”

Section: Epidemiologymentioning

confidence: 99%

Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome

Chávez-Íñiguez

Cabrera-Aguilar

García-García

et al. 2020

jrenhep

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Leptospirosis is considered a zoonosis acquired predominantly from contaminated surfaces and water, more commonly in emerging countries with limited sanitary conditions. Leptospira in the host unleashes an immune response that explains the symptoms and clinical signs; once it reaches the kidney and liver tissue, it can manifest with alterations that lead to acute and chronic diseases in both organs. Weil’s syndrome is the best known clinical manifestation with jaundice and acute kidney injury that could lead to multiple organ failure and death. For its diagnosis, there are simplified scores such as the SPiRO score, the microbiological criteria by microscopy or serological tests; the treatment focuses on antibiotics and, if necessary, provides organic support until the infection is curtailed. The purpose of this review was to address the impact of Lep-tospira infection on the kidney and liver, the mechanisms of organ damage, the clinical presentation, and diagnosis and management of this disease.

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Section: Epidemiologymentioning

confidence: 99%