Thirty-six thumbs with symptomatic osteoarthritis of the first carpometacarpal joint were treated either by trapezio-metacarpal arthrodesis (n = 18) or resection-tendon-interposition arthroplasty (n = 18). The mean follow-up of the 29 patients was 42 months. With the data available, we could not find any difference in the outcome of either procedure. In the majority of cases, the main aim of the operation, relief of pain, was achieved, the patients were satisfied and pleased with the functional result of the operation. No difference in grip strength between the operated and the normal contralateral hand could be established. Nevertheless, the arthrodesis seems to be the procedure causing fewer problems (only one patient not completely satisfied) and is therefore preferred over the resection-tendon-interposition arthroplasty.