Additive Manufacturing (AM) is revolutionizing aerospace, transportation, and biomedical sectors with its potential to create complex geometries. However, the metallic materials currently used in AM are not intended for high‐energy beam processes, suggesting performance improvement. The development of materials for AM still faces challenge because of the inefficient trial‐and‐error conventional methods. This review examines the challenges and current state of materials including aluminum alloys, titanium alloys, superalloys, and high‐entropy alloys (HEA) in AM, and summarizes the high‐throughput methods in alloy development for AM. In addition, the advantages of high‐throughput preparation technology in improving the properties and optimizing the microstructure mechanism of major additive manufacturing alloys are described. This article concludes by emphasizing the importance of high‐throughput techniques in pushing the boundaries of AM materials development, pointing toward a future of more effective and innovative material solutions.