Welders are at increased risk for invasive pneumococcal disease

Wong, Alexander; Marrie, Thomas J.; Garg, Sipi; Kellner, James D.; Tyrrell, Gregory J.

doi:10.1016/j.ijid.2010.02.2268

Cited by 55 publications

(49 citation statements)

References 11 publications

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“…2,4,24 We focused on S pneumoniae because this bacterium is the most common cause of community-acquired pneumonia in adults. 10 In addition, a review of all patients presenting with invasive pneumococcal disease (IPD) in Alberta (Canada) from 2000 to 2004 by Wong et al 25 reported a 2.7-fold greater incidence of IPD in welders; of the 18 welders with IPD, 17 had bacteremic pneumococcal pneumonia, 1 had meningitis, and 1 died of pneumococcal infection. Pneumococcal infection in welders remains a problem.…”

Section: Discussionmentioning

confidence: 99%

Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae

Suri

Periselneris

Lanone

et al. 2016

Journal of Allergy and Clinical Immunology

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Background Welders are at increased risk of pneumococcal pneumonia. The mechanism for this association is not known. The capacity of pneumococci to adhere to and infect lower airway cells is mediated by host-expressed platelet-activating factor receptor (PAFR). Objective We sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model. Methods The oxidative potential of MS-WF was assessed by their capacity to reduce antioxidants in vitro. Pneumococcal adhesion and infection of A549, BEAS-2B, and primary human bronchial airway cells were assessed by means of quantitative bacterial culture and expressed as colony-forming units (CFU). After intranasal instillation of MS-WF, mice were infected with Streptococcus pneumoniae, and bronchoalveolar lavage fluid (BALF) and lung CFU values were determined. PAFR protein levels were assessed by using immunofluorescence and immunohistochemistry, and PAFR mRNA expression was assessed by using quantitative PCR. PAFR was blocked by CV-3988, and oxidative stress was attenuated by N-acetylcysteine. Results: MS-WF exhibited high oxidative potential. In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. Both CV-3988 and N-acetylcysteine reduced MS-WF–stimulated pneumococcal adhesion and infection of airway cells. MS-WF increased mouse lung PAFR mRNA expression and increased BALF and lung pneumococcal CFU values. In MS-WF–exposed mice CV-3988 reduced BALF CFU values. Conclusions Hypersusceptibility of welders to pneumococcal pneumonia is in part mediated by the capacity of welding fumes to increase PAFR-dependent pneumococcal adhesion and infection of lower airway cells.

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Section: Discussionmentioning

confidence: 99%

Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae

Suri

Periselneris

Lanone

et al. 2016

Journal of Allergy and Clinical Immunology

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“…4 Unarguably, respiratory diseases encompass some of the communicable and non-communicable leading causes of death worldwide; while industrialization is enhancing the phenomenon of increased risk, especially in urban areas. [5][6][7] Tobacco smoke remains a controversial subject, but also unarguably a risk factor. The need for clinical toxicity testing has been advocated, not-with-standing that haematological and haemorrheological changes possibly associated with cigarette smoking have long been speculated.…”

Section: Issues Of Management and Monitoring By Laboratory Methods Inmentioning

confidence: 99%

Issues of management and monitoring by laboratory methods in respiratory medicine: editorial introduction

Nwose

2016

Int J Res Med Sci

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“…4 Similar reports relating to lobar and pneumococcal infection in welders subsequently emerged from Sweden 5 and Canada. 6 pathway and now enrols all their students in the MBBS programme with the option of undertaking research during their course, leading to a master's degree, with the potential to expand this for the few who have the aptitude and ability to do so. 3 In summary, encouraging highperforming students to enrol in a combined professional and research medical degree can only be a sustainable way to develop skilled clinician scientists if postgraduate pathways to academic medicine are clearly defined.…”

Section: Community-acquired Pneumonia and Weldingmentioning

confidence: 99%

Community-acquired pneumonia and welding

Palmer

Cosgrove²

2013

Clinical Medicine

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Welders are at increased risk for invasive pneumococcal disease

Abstract: Welders, particularly those who smoke, are at increased risk of IPD and should be considered for routine administration of the pneumococcal polysaccharide vaccine. Ongoing workplace measures to reduce exposure to metal fumes and promote smoking cessation should be reinforced.

Cited by 55 publications

References 11 publications

Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae

Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae

Issues of management and monitoring by laboratory methods in respiratory medicine: editorial introduction

Community-acquired pneumonia and welding

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