Objective: To compare the mechanical strength of joints made by conventional soldering with those made by alternative, more biocompatible, methods (spot, tungsten inert gas [TIG] and laser welding), and to compare the microstructural morphology of wires welded with these techniques. Design: In vitro, laboratory study. Methods: Forty stainless-steel wire segments with 0.8-mm diameter were joined by silver soldering, spot, laser and TIG welding. Ten specimens were produced for each one. Tensile strength test was performed 24 h after welding on the Emic DL2000™ universal testing machine, using a load cell of 1000 N with a crosshead speed of 10 mm/min. Results: The highest tensile strength mean values were obtained with silver soldering (532 N), next were laser (420 N), spot (301 N) and TIG (296 N) welding. Statistically significant differences were observed between the groups; the Dunn post-hoc test revealed differences between laser and spot welding ( p=0.046), laser and TIG ( p = 0.016), spot and silver ( p <0.001), and silver and TIG ( p <0.001). Conclusion: Laser welding strength is high, and comparable to silver welding. Spot and TIG techniques present comparable and significantly lower strengths. The four methods presented resistance values compatible with orthodontic use. The microstructural morphology is different for each technique. The association between the mechanical performance and the microstructure evaluation shows that laser presented the highest quality joint.