This paper presents a numerical parametric study on cold-formed steel built-up beams subjected to bending. The cold-formed steel built-up elements are efficient structural elements that are easy to assemble during the construction process, ensuring material savings and potential for standardization, thus making them more suitable for mass production. A new technological solution for built-up steel beams with webs made of corrugated steel sheets and flanges made of cold-formed steel profiles, assembled through two welding techniques, was proposed within the well-formed research project. This solution can be used as a component of single or low-rise multi-story frames, purlins, or secondary beams. The experimental program investigated seven full-scale beams, two of which have web openings. The web openings were introduced for the case when these members are used as secondary beams in floor systems. The paper investigates these types of beams with web openings using parametric numerical analyses. A numerical model validated against experimental tests was proposed to carry out a parametric study through nonlinear finite element analysis, considering initial imperfections and considering the strain-hardening characteristics of the steel components. The influence of different components was analyzed through the parametric study. Beams with three lengths were studied, i.e., (1) 6000 mm, (2) 7500 mm, and (3) 9000 mm. In total, 61 simulations were found. The article highlights the parameters that contribute significantly to the stiffness and capacity of the built-up cold-formed steel elements. The weakest component was concluded to be the thickness of the corrugated web, while the presence of the stiffened web opening reduced the bearing capacity by approximately 5–10%.