The global demand for improvement in the welfare conditions of broilers has generated the necessity to implement alternative rearing systems as well as less intensive growth hybrids. The majority of the data on alternative farming methods, notwithstanding their abundance, are the result of small-scale experiments. The present extended field study examined the effect of two different industrial farming systems on broilers’ antioxidant status, performance, and meat quality, including 13 replicates of each industrial breeding system (intensive conventional; free range) and two different chicken genotypes (fast growth; slow growth). The duration of the study was 51 months, and the total number of broilers was 260.000 for the conventional and 78.000 for the free-range system. The results showed that fast-growth chicks demonstrated a more satisfactory performance (in terms of body weight gain (BWG) and feed conversion ratio (FCR) with p ≤ 0.001), reduced serum lipid oxidation (p ≤ 0.05), and more tender meat. Contrarily, slow-growth chickens presented significantly higher total antioxidant capacity (TAC) in serum and thigh muscle (p ≤ 0.001), significantly lower (p ≤ 0.05) thigh muscle oxidation (in terms of thiobarbituric acid reactive substances, TBARS), increased protein and decreased fat content (p ≤ 0.05), and better smell, taste, color, and texture. In conclusion, the free-range farming system for slow-growth chickens may result in an overall higher nutritional value, sensory score, and serum and thigh muscle antioxidant profile than the conventional farming system for fast-growth broilers. However, fast-growth broilers exhibit better performance and might undergo less stress.