Welfare of the minipig with special reference to use in regulatory toxicology studies

Ellegaard, Lars; Cunningham, Andrew; Edwards, Sandra A.; Grand, Nanna; Nevalainen, Timo; Prescott, Mark J.; Schuurman, T.

doi:10.1016/j.vascn.2010.05.006

Cited by 53 publications

(25 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 With the increasing ethical concerns regarding the use of primates in non-clinical testing, attention has been increasingly focused on the potential use of minipigs as non-rodent alternatives for pharmaceutical testing. [13][14][15][16][17] As such, minipigs are becoming more frequently used for toxicological and PK studies of small molecules. [18][19][20] Recently, minipigs have been used to test the immunogenicity of therapeutic proteins; 21,22 however, limited data exist for the pharmacokinetics of macromolecules in minipigs.…”

Section: Resultsmentioning

confidence: 99%

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Zheng¹,

Tesar²,

Benincosa

et al. 2012

mAbs

124

110

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Zheng¹,

Tesar²,

Benincosa

et al. 2012

mAbs

124

110

View full text Add to dashboard Cite

show abstract

“…In contrast, biperiden is administered orally. Oral administration in food is the least stressful and preferred way to administer drugs to pigs provided that the drug-containing food does not induce food aversion and is palatable [28]. As we would like to know whether Göttingen minipigs are suitable for studying cognitive function, we tested whether 1) conventional pigs and age-matched Göttingen minipigs learn the holeboard task at a similar speed and to a similar asymptotic performance level, and 2) whether orally administered biperiden transiently impairs spatial memory in pigs.…”

Section: Introductionmentioning

confidence: 99%

Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden

et al. 2013

View full text Add to dashboard Cite

BackgroundThe pig is emerging as a model species that bridges the gap between rodents and humans in research. In particular, the miniature pig (referred to hereafter as the minipig) is increasingly being used as non-rodent species in pharmacological and toxicological studies. However, there is as yet a lack of validated behavioral tests for pigs, although there is evidence that the spatial holeboard task can be used to assess the working and reference memory of pigs. In the present study, we compared the learning performance of commercial pigs and Göttingen minipigs in a holeboard task.MethodsBiperiden, a muscarinic M1 receptor blocker, is used to induce impairments in cognitive function in animal research. The two groups of pigs were treated orally with increasing doses of biperiden (0.05 – 20 mg.kg-1) after they had reached asymptotic performance in the holeboard task.ResultsBoth the conventional pigs and the Göttingen minipigs learned the holeboard task, reaching nearly errorless asymptotic working and reference memory performance within approximately 100 acquisition trials. Biperiden treatment affected reference, but not working, memory, increasing trial duration and the latency to first hole visit at doses ≥ 5 mg.kg-1.ConclusionBoth pig breeds learned the holeboard task and had a comparable performance. Biperiden had only a minor effect on holeboard performance overall, and mainly on reference memory performance. The effectiveness needs to be evaluated further before definitive conclusions can be drawn about the ability of this potential cognition impairer in pigs.

show abstract

“…There is growing interest in the use of minipigs as a non-rodent species for non-clinical safety evaluation of (bio) pharmaceuticals and chemicals [3][4][5]7,[20][21][22]. Here we report a first effort to assess the feasibility of using minipigs as an alternative non-rodent species for studying immunotoxicity of pharmaceuticals.…”

Section: Discussionmentioning

confidence: 99%

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

2013

Clin Exp Pharmacol

View full text Add to dashboard Cite

Introduction: There is a growing interest in the minipig as a non-rodent species in the safety assessment of (bio) pharmaceuticals and (agro) chemicals. For (bio) pharmaceuticals the need to evaluate the potential adverse effects on the immune system is an increasingly important aspect of safety evaluation. In the present study, cyclosporin A and Dexamethasone were used as model compounds to examine whether the regulatory endpoints requested for immunotoxicity testing can be tested in the Göttingen minipig.

show abstract

Welfare of the minipig with special reference to use in regulatory toxicology studies

Cited by 53 publications

References 37 publications

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

Contact Info

Product

Resources

About