Well-differentiated papillary mesothelioma occurring in the tunica vaginalis of the testis with contralateral atypical mesothelial hyperplasia

Tolhurst, Stephen R.; Lotan, Tamara L.; Rapp, David E.; Lyon, Mark B.; Orvieto, Marcelo A.; Gerber, Glenn S.; Sokoloff, Mitchell H.

doi:10.1016/j.urolonc.2005.06.021

Cited by 38 publications

(36 citation statements)

References 13 publications

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“…11,13 To our knowledge, there have only been 11 well-documented cases reported as paratesticular 'well-differentiated papillary mesothelioma' to date. 3,6,8,12,[15][16][17][18][19][20][21] However, on the basis of microscopic descriptions and illustrations five had more complex areas within them, similar to the cases reported here. 6,12,16,18,20 Among the 11 cases, only one recurred and progressed to diffuse malignant mesothelioma.…”

supporting

confidence: 78%

“…[4][5][6] Paratesticular mesotheliomas, which comprise less than 1% of all cases of mesothelioma, are usually malignant and aggressive tumors that are morphologically identical to mesotheliomas at other sites, and may therefore show an epithelial, spindle cell or biphasic morphology.…”

Section: Discussionmentioning

confidence: 99%

“…2,[8][9][10][11][12] In other reports, a tubular architecture was included as part of the histological spectrum of changes that can be seen in this entity. 1,3,6 In the original series of Daya et al, some cases with more complex architectural patterns, including focal solid growth, were also described. However, the authors acknowledged that the lack of long-term follow-up in their series precluded reaching definite conclusions on whether those cases with more complex architecture can be considered with certainty as welldifferentiated papillary mesotheliomas, and therefore as indolent tumors, or whether they should be considered as diffuse mesotheliomas.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,4,6,7,8) the tumor presented as a solitary polypoid papillary mass protruding out of the surface of the tunica vaginalis, and in one case multiple separate nodules were present (no. 5) (Figures 1a and b).…”

Section: Pathological Findingsmentioning

confidence: 99%

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Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential

2010

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Well-differentiated papillary mesotheliomas have rarely been reported to involve the testis tunica vaginalis. While the classic histology of the originally described well-differentiated papillary mesotheliomas consisted of papillae lined by a single layer of bland cuboidal cells, more complex architectural patterns have been described. This report details our experience with eight paratesticular mesotheliomas that span the histological spectrum from classic well-differentiated papillary mesotheliomas to those with more complex patterns. We attempt to determine whether there are prognostic or immunohistochemical differences between these lesions and 28 diffuse malignant mesotheliomas. All cases had papillary/tubulopapillary in addition to more complex architectures (cribriform, condensed) and none showed evidence of invasion. Mitotic figures were present in seven cases and averaged 2.1 mitosis per 50 h.p.f. All cases showed r1% of positive cells staining for Ki-67 and p53, and only one case stained positive for GLUT-1 in comparison with 50% positivity for GLUT-1 in diffuse mesotheliomas. Of five patients with follow-up information of more than 1 year, three patients were alive at 2, 3 and 9 years, and two died of unknown causes at 5 and 47 years, suggesting that these lesions behave more indolently than typical malignant mesotheliomas of the tunica vaginalis. If these cases were diffuse malignant mesotheliomas, one would have expected at least some of the patients to have died of disease within a couple of years after diagnosis. However, detailed and long-term follow-up were not sufficiently available to reach definitive conclusions on the true biological behavior of these tumors. The morphological continuum noted between our cases and classic well-differentiated papillary mesotheliomas, combined with their immunohistochemical profile and indolent behavior, contrasts with that of diffuse malignant mesotheliomas. We propose that these tunica vaginalis mesotheliomas, which are more complex than the classic well-differentiated papillary mesotheliomas, and yet are not overtly histologically malignant, be classified as 'mesotheliomas of uncertain malignant potential'.

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supporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Pathological Findingsmentioning

confidence: 99%

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Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential

2010

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“…Microscopic pattern is expressed in the appearance of papillary, solid, alveolar, glandular (tubular), cystic, myxomatous, fibrous, perithelial, sarcomatoid and angioma-like structures, which in some cases may dominate [74,80,101,115]. All this creates considerable polymorphism of the microstructure of the tumor [96].…”

Section: Pathological Anatomy: the Macroscopic And Cyto-histopathologmentioning

confidence: 99%

Testicular Mesothelioma

Alexander¹

2012

Mesotheliomas - Synonyms and Definition, Epidemiology, Etiology, Pathogenesis, Cyto-Histopathological Features, Clinic, Diagnos

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Fine‐needle aspiration of a well‐differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature

Wheeler

Burroughs

2009

Diagnostic Cytopathology

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Well-differentiated papillary mesothelioma (WDPM) is an uncommon subtype of epithelioid mesothelioma. In contrast to malignant epithelioid mesothelioma, WDPM has a low malignant potential and an indolent clinical course. WDPM may be difficult to diagnose and differentiate from benign reactive mesothelial cells and other malignant neoplasm on cytology specimens due to the presence of papillary or tubulopapillary clusters of tumor cells. We report a case of a 63-year-old Asian male with a slowly growing left inguinal hernia mass for several years and a concurrent 8 cm mass in the peritoneal wall. The cytology of ultrasound-guided fine-needle aspiration (FNA) of the left inguinal hernia and peritoneal masse reveal cellular specimens with numerous individual and tubulopapillary clusters of epithelioid mesothelial cells in a background of scant hyalinized material. Tumor cells show minimal cytological atypia. The differential diagnoses are broad and include reactive mesothelial cells, WDPM, and other malignant neoplasm. The follow-up surgical resection of masses reveals features of WDMP. It is important to recognize this entity in the differential diagnosis, because the clinical management of WDPM is quite different from that of malignant neoplasm. On the basis of the published data in the literature, it suggests that in male patients, the WDPM occurs predominantly in pleural cavity of older men in their 50s, and about half of the patients have history of asbestos exposure. However, the data is limited and insufficient for a definitive conclusion.

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Well-differentiated papillary mesothelioma occurring in the tunica vaginalis of the testis with contralateral atypical mesothelial hyperplasia

Cited by 38 publications

References 13 publications

Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential

Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential

Testicular Mesothelioma

Fine‐needle aspiration of a well‐differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature

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