Well-Dispersed Fe3O4/SiO2 Nanoparticles Synthesized by a Mechanical Stirring and Ultrasonication Assisted Stöber Method

Sun, Xuejiao; Liu, Futian; Sun, Li; Wang, Qun; Ding, Yongling

doi:10.1007/s10904-011-9609-0

Cited by 20 publications

(16 citation statements)

References 18 publications

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“…It has been shown also that coating of magnetic particles with non-magnetic materials such as silica influences the value of magnetization due to the quenching of surface moments [28]. The thicker silica shell-the lower the saturation magnetization [8]. Barick et al [22] reported on the preparation of dispersed iron oxide Fe 2 O 3 nanoparticles in silica matrix using sol-gel process.…”

Section: Magnetization Measurementsmentioning

confidence: 99%

“…Variety of the inorganic and polymeric materials has been reported as possible carriers for magnetic materials. Among them silica, an inorganic carrier, seems to be interesting supporting material, which can be easily prepared and retains stability in most chemical and biological environments [7,8]. It has been demonstrated that the formation of a passive coating of inert materials such as silica on the surfaces of iron oxide nanoparticles could help to prevent their aggregation in liquids and improve their chemical stability [9].…”

Section: Introductionmentioning

confidence: 99%

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Sol–gel synthesis of iron oxide–silica composite microstructures

Lewandowska

Staszewska

Kępczyński

et al. 2012

J Sol-Gel Sci Technol

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Spherical silica particles doped with iron oxide have been synthesized via base-catalyzed one-pot sol-gel process using tetraethoxysilane (TEOS) and iron(III) ethoxide (ITE) as co-precursors. In the modified Stöber process adopted, depending on the concentration of ITE in the starting composition, materials of various morphologies were observed under a scanning electron microscope and an atomic force microscope. The presence of ITE significantly affected the formation process of particulate silica; the spherical particles were formed accompanied by the copresence of irregular-shaped finer aggregates. The fraction of the aggregates with rough surfaces increased with an increase of the ITE content in the reaction mixture. Both the spherical particles and irregular-shaped aggregates contained iron hydroxide and they exhibited paramagnetic behavior. The chemical composition and physicochemical properties of the materials were determined using various complementary spectroscopic methods. Keywords Iron(III) ethoxide Á Sol-gel Á Microstructures Á Silica Electronic supplementary material The online version of this article (

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Section: Magnetization Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sol–gel synthesis of iron oxide–silica composite microstructures

Lewandowska

Staszewska

Kępczyński

et al. 2012

J Sol-Gel Sci Technol

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“…The surface modification was aiming to overcome the colloidal instability of Fe 3 O 4 NPs induced by the magnetic dipole interaction and their inherently large surface energy. [21][22][23] Previously we have succeeded in the synthesis of 3-55 aminopropyltriethoxysilane (APTS)-and polyethyleneimine (PEI)-coated Fe 3 O 4 NPs via a one-pot hydrothermal approach. 24,25 The dense primary amine groups on the surface of Fe 3 O 4 NPs rendered by the APTS or PEI coating not only endow the NPs with colloidal stability, but also mediates convenient modification 60 and functionalization of the particle surfaces for various biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging

Jia

et al. 2015

J. Mater. Chem. B

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We present the polyethyleneimine (PEI)-assisted synthesis of folic acid (FA)-functionalized iron oxide (Fe 3 O 4 ) nanoparticles (NPs) with ultrahigh relaxivity for in vivo targeted tumor magnetic resonance (MR) 10 imaging. In this work, water-dispersible and stable Fe 3 O 4 NPs were synthesized in the presence of PEI via a facile mild reduction approach. The surface PEI coating afforded the formed Fe 3 O 4 NPs with the ability to be functionalized with polyethylene glycol (PEG)-linked FA and fluorescein isothiocyanate (FI). A further acetylation step to neutralize the remaining PEI surface amines gave rise to the formation of multifunctional FA-functionalized Fe 3 O 4 NPs, which were subsequently characterized via different 15 methods. We show that the developed FA-functionalized Fe 3 O 4 NPs have a good water-dispersibility, good colloidal stability, ultrahigh r 2 relaxivity (475.92 mM -1 s -1 ), and good hemocompatibility and cytocompatibility in the studied concentration range. The targeting specificity of the FA-modified Fe 3 O 4 NPs to FA receptors (FAR)-overexpressing HeLa cells (a human cervical carcinoma cell line) was subsequently validated by flow cytometry and confocal microscopy. Significantly, the developed FA-20 modified Fe 3 O 4 NPs can be used as a nanoprobe for targeted MR imaging of HeLa cells in vitro and the xenografted tumor model in vivo via an active FA-mediated targeting strategy. The developed multifunctional FA-modified Fe 3 O 4 NPs with an ultrahigh r 2 relaxivity may be used as an efficient nanoprobe for targeted MR imaging of various kinds of FAR-overexpressing tumors. 65 Fe 3 O 4 NPs were able to be covalently linked with PEGylated folic acid (FA) 28 or hyaluronic acid (HA) 29 for targeted MR

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“…During the past decades, tremendous investigations have also been performed in magnetic Fe 3 O 4 nanoparticles . The preparation methods for Fe 3 O 4 nanocarriers include coprecipitation, ultrasonic precipitation, sol‐gel, microemulsions, hydrothermal methods, and etc.…”

Section: Anticancer Drug Delivery Systems Based On Inorganic Nanocarrmentioning

confidence: 99%

“…Magnetic nanoparticles are attractive to researchers from different disciplines, including catalysis, data storage, and magnetic separation. Currently, due to their promising biocompatibility, Fe 3 O 4 nanoparticles are also commonly used in biological applications such as magnetic resonance imaging (MRI), cell labeling, and cancer treatment . When used in biological systems, Fe 3 O 4 nanoparticles require proper surface coating or other protection strategies to keep their stability, because the nanoparticles display high chemical activity and could be easily oxidized.…”

Section: Anticancer Drug Delivery Systems Based On Inorganic Nanocarrmentioning

confidence: 99%

Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers

et al. 2017

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In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018

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Well-Dispersed Fe3O4/SiO2 Nanoparticles Synthesized by a Mechanical Stirring and Ultrasonication Assisted Stöber Method

Cited by 20 publications

References 18 publications

Sol–gel synthesis of iron oxide–silica composite microstructures

Sol–gel synthesis of iron oxide–silica composite microstructures

Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging

Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers

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