The actual scientific and production task is the prevention of loss wellbore stability for West Siberia companies. The process of well drilling in clay intervals is consisting of many additional actions for stabilization wellbore. There is analysis of wells with problems due to caving and falling in this article. It was allowed to determine that almost 50 % of drilling time is non-production time, which connects with clay warping. The design of new inhibitory bath compound is necessary to avoid loss wellbore stability. It was applied Box-Behnken method for planning of experiment and for a mathematical analysis of synergistic effects components and thermo-baric conditions among each other. The result of this work is the development of the optimal composition of the bath to stabilize clay rocks for more than 13 hours, which is enough for drilling complicated intervals.