Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system

Xia, Wei; Chang, Jiang

doi:10.1016/j.jconrel.2005.11.002

Cited by 387 publications

(271 citation statements)

References 22 publications

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“…The porous biomaterials with large surface areas and large pore volumes are good candidates for drug delivery systems [2][3][4]. Drug carriers require biocompatibility and well defined morphological characteristics, and here the sol-gel methods of mesoporous silica materials production offer the simplicity of preparation and ease of control of their pore sizes adapted to the different drug molecules [5,6].…”

Section: Introductionmentioning

confidence: 99%

Pore ordering in mesoporous matrices induced by different directing agents

et al. 2014

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Mesoporous silica particles of MCM-41 type were synthesized by sol-gel method from tetraethyl orthosilicate (TEOS) in 2-methoxyethanol and deionized water mixture in base conditions at room temperature. Ammonia or sodium hydroxides were used as catalysts and cetyl-trimethylammonium bromide (CTAB) and n-dodecyl-trimethylammonium bromide (DTAB) as structure directing agents. The porosities and the ordered structure have been analyzed using transmission and scanning electron microscopy, small angle neutron and Xray diffraction, nitrogen adsorption, thermal analysis and FTIR spectroscopy. The samples consist of spherical particles of sub-micrometer size, with radially arranged pores. The comparison of the effect of the different surfactants and catalysts shows that by varying the surfactant type and their proportion, the pore sizes can be controlled. As compared to the commonly used ammonia catalyst, the use of NaOH as catalyst results in a much smaller porosity of the as-prepared materials. These materials are not resisting to the heat treatment at 700 ºC used for the template removal, and the ordered porous structure is completely lost.

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Section: Introductionmentioning

confidence: 99%

Pore ordering in mesoporous matrices induced by different directing agents

et al. 2014

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“…One factor is the CS shell on the surface of microspheres which appears to inhibit the BSA release from the microsphere. The other factor is that CS has the ability to induce the formation of nano-size apatite in biological solution (PBS or SBF; see in figure 8), and these nano-size apatite particles may bind proteins by the chemical side groups OH 2 , PO 3À 4 and CO 2À 3 , thereby slowing BSA release from microspheres [34,35]. Our recent study has further confirmed that the forme apatite plays an important role in improving protein delivery [27].…”

Section: The Formation Mechanism Of the In Situmentioning

confidence: 64%

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

Fan

Gelinsky

et al. 2011

J. R. Soc. Interface.

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The efficient loading and sustained release of proteins from bioactive microspheres remain a significant challenge. In this study, we have developed bioactive microspheres which can be loaded with protein and then have a controlled rate of protein release into a surrounding medium. This was achieved by preparing a bioactive microsphere system with core-shell structure, combining a calcium silicate (CS) shell with an alginate (A) core by a one-step in situ method. The result was to improve the microspheres' protein adsorption and release, which yielded a highly bioactive material with potential uses in bone repair applications. The composition and the core-shell structure, as well as the formation mechanism of the obtained CS -A microspheres, were investigated by X-ray diffraction, optical microscopy, scanning electron microscopy, energy dispersive spectrometer dot and line-scanning analysis. The protein loading efficiency reached 75 per cent in CS -A microspheres with a core-shell structure by the in situ method. This is significantly higher than that of pure A or CS -A microspheres prepared by non-in situ method, which lack a core-shell structure. CS -A microspheres with a core-shell structure showed a significant decrease in the burst release of proteins, maintaining sustained release profile in phosphate-buffered saline (PBS) at both pH 7.4 and 4.3, compared with the controls. The protein release from CS -A microspheres is predominantly controlled by a Fickian diffusion mechanism. The CS -A microspheres with a core-shell structure were shown to have improved apatite-mineralization in simulated body fluids compared with the controls, most probably owing to the existence of bioactive CS shell on the surface of the microspheres. Our results indicate that the core-shell structure of CS -A microspheres play an important role in enhancing protein delivery and mineralization, which makes these composite materials promising candidates for application in bone tissue regeneration.

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“…It is used as artificial bone material because of its biocompatibility, osteoconductivity and bioactivity, i.e., its ability to form direct bond with tissue (Puvvada et al 2010;Sonju Clasen and Ruyter 1997). Due to their biocompatibility, they are promising materials in separation techniques, e.g., for the removal of numerous heavy metal ions (especially lead and cadmium ions) from waste water through ion-exchange process (Puvvada et al 2010), and in drug delivery systems for the delivery of anti-tumor agents and antibodies in the treatment of osteomyelitis (Xia and Chang 2006;Yang et al 2005;Yamashita et al 1998). The properties and applications of synthetically prepared HA have been reported to be influenced by the size and morphological characteristics of their particles (Ramachandra et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of temperature on morphology of triethanolamine-assisted synthesized hydroxyapatite nanoparticles

et al. 2012

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Hydroxyapatite (HA) nanoparticles have been synthesized using ortho-phosphoric acid as the source of PO 4 3-ions, and calcium chloride, suitably complexed with triethanolamine, as the calcium source. The effect of temperature on the morphology of the product has been investigated. The chemical compositions of the samples have been established through Fourier transform infrared spectroscopy. This study reveals that A-type and B-type carbonate substitution are present in HA samples and the concentration of carbonate ions decrease with rise in temperature. Morphological analyses by TEM studies suggest that the average lengths and widths of the needle-shaped particles size increases with temperature up to 50°C, while a morphological change of the particles from needle to spherical shape is observed on raising the temperature above 50°C. This change in morphology has been assigned to the apparent solubility of HA at these temperatures, which has been studied by the determination of thermochemical properties of the reaction system by endpoint conductivity and electrophoretic mobility measurements.

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Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system

Cited by 387 publications

References 22 publications

Pore ordering in mesoporous matrices induced by different directing agents

Pore ordering in mesoporous matrices induced by different directing agents

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

Effect of temperature on morphology of triethanolamine-assisted synthesized hydroxyapatite nanoparticles

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