2013
DOI: 10.1161/strokeaha.112.680652
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Wellcome Trust Genome-Wide Association Study of Ischemic Stroke

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Cited by 9 publications
(7 citation statements)
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“…The association of HDAC9 rs11984041 with ischaemic stroke was established in a large-GWAS including several study populations achieving a combined p-value of 1.87 × 10 -11 . The OR was 1.42 (95% CI 1.28-1.57) [26], which is in line with our finding of an unconditional OR of 1.32 (95% CI 1.00-1.70). HDAC9 belongs to a large family of genes which are responsible for deacetylation of histones and thus for regulation of chromatin structure and gene transcription [24].…”
Section: Comparison With Previous Studiessupporting
confidence: 91%
“…The association of HDAC9 rs11984041 with ischaemic stroke was established in a large-GWAS including several study populations achieving a combined p-value of 1.87 × 10 -11 . The OR was 1.42 (95% CI 1.28-1.57) [26], which is in line with our finding of an unconditional OR of 1.32 (95% CI 1.00-1.70). HDAC9 belongs to a large family of genes which are responsible for deacetylation of histones and thus for regulation of chromatin structure and gene transcription [24].…”
Section: Comparison With Previous Studiessupporting
confidence: 91%
“…Until very recently, main technique used to identify underlying genetic predisposing conditions for ischemic stroke was the candidate gene method : SNP(s) are identified in a proposed candidate gene, and the frequency of the SNPs in patients with stroke compared with controls was then determined [118] .…”
Section: Polygenic Conditionsmentioning
confidence: 99%
“…This can be thought of as a large series of candidate gene studies performed in a single experiment on an array based format [119] . A great advantage of GWAS approach is that it allows associations between completely novel chromosomal loci and disease [118] . GWAS have provided the strongest evidence for loci associated with the common form of ischemic stroke.…”
Section: Polygenic Conditionsmentioning
confidence: 99%
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“…Sodium valproate therapy in humans reduces the prevalence of stroke and MI compared with treatment with other antiepileptic drugs [97]. Although several studies indicate that HDAC9 is a susceptibility gene for ischemic stroke, additional functional studies should be performed to understand the SNPs in HDAC9 that increase the risk of stroke [98].…”
Section: Histone Deacetylase 9 Genementioning
confidence: 99%