Wells’ syndrome: a clinical and histopathologic review of seven cases

Moossavi, Meena; Mehregan, Darius

doi:10.1046/j.1365-4362.2003.01705.x

Cited by 97 publications

(133 citation statements)

References 43 publications

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“…The etiology and pathogenesis are unknown. Wells' syndrome may be idiopathic or associated with infections, arthropod bites, drug administration, hematologic disorders, or surgery (5,6). However, in approximately one half of reported cases, there is no identifiable precipitating factor.…”

Section: Introductionmentioning

confidence: 99%

Wells� syndrome in childhood: two case reports with review of the literature

Farina¹

2014

CDERM

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SummaryWells' syndrome, or eosinophilic cellulitis, is a rare disorder manifesting with acute erythematous and edematous plaques which resolve completely. Bullous lesions are uncommon, especially in childhood. We present two pediatric cases of bullous Wells' syndrome, one 3-year-old boy with atypical cutaneous manifestations and one 6-month-old girl with typical skin lesions. No trigger factors could be identified in both cases. Treatment with topical and systemic steroids was performed. Both patients had no recurrences after two years. Fortyfive pediatric cases of Wells' syndrome have been reported in the literature with an average age of onset of five years. In only seven cases bullous lesions were present. In about half of the patients a precipitating factor has been identified, including infections, arthropod bites, drug administration and hematologic disorders.

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Section: Introductionmentioning

confidence: 99%

Wells� syndrome in childhood: two case reports with review of the literature

Farina¹

2014

CDERM

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“…For patients who fail to completely resolve on gluco corticoids or relapse often enough, treatment with minocycline, dapsone, antihistamines, cyclosporine or interferon alpha might be beneficial (Stetson 2003). Minocycline and doxycycline have been used in iso lated cases of the human disease (Moossavi and Mehregan 2003).…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic dermatitis with edema (WellsMike syndrome) possibly triggered by cooked fish in a dog

Giannoulopoulos

Farmaki

Koutinas

et al. 2017

J Hellenic Vet Med Soc

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A 2-year old intact female mongrel dog was admitted with multifocal skin lesions appearing suddenly and extending symmetrically over most of the body. The dog was living indoors and one day before the admission it had consumed cooked fish. Neither medication, nor vaccination had been given to the dog, at least during the last 3 months. Physical examination revealed only non-pruritic and non-painful macules, papules and plaques that were distributed mainly over the head, pinnae, neck and thorax. The lesions were annular, aeriform or serpiginous with a tendency to coalesce. Skin histopathology (H-E) revealed a superficial dermal edema, post-capillary venule congestion and perivascular to interstitial eosinophilic dermatitis as the main pattern. The dog was initially placed on oral vitamin E, sulphasalazine and doxycycline, but to no avail. As soon as the diagnosis of eosinophilic dermatitis with edema was confirmed by histopathology, the former treatment stopped and oral prednisolone was given for two months during which there was a remarkable improvement of skin lesions and complete disappearance with no relapse. The cooked fish, consumed by the dog the night before the incident, was assumed to be the cause of the acute eosinophilic hypersensitivity reaction.

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“…A vasculite está consistentemente ausente. 4,5 As figuras em chama são sugestivas, porém não patognomônicas, da SW e podem ser encontradas, em número variável, apenas nas fases aguda e subaguda. São também descritas em quadros tão diversos como penfigóide bolhoso, picadas de inseto, eczemas, dermatofitoses, herpes gestacional e escabiose.…”

Section: Que Síndrome é Esta? Síndrome De Wellsunclassified

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Silva

Ottoni

Andrade-Filho

et al. 2007

An. Bras. Dermatol.

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575An Bras Dermatol. 2007;82(6):575-8. Síndrome em questão RELATO DO CASOPaciente do sexo masculino, 68 anos, branco, com quadro cutâneo de início súbito há três anos, pruriginoso, constituído por placa eritêmato-violácea na face posterior do antebraço D (Figura 1) e lesões vésico-bolhosas, tensas, com conteúdo seroso ou serossangüinolento, nas mãos (Figura 2), pés e abdômen. As mucosas estavam poupadas, o paciente apresentavase afebril e em bom estado geral, não fazendo uso regular de qualquer medicação. O exame anátomo-patológico revelou edema acentuado da derme superficial e infiltrado dérmico difuso e intenso contendo mononucleares e eosinófilos, sem evidência de vasculite (Figura 3). O mesmo tipo de processo inflamatório estendia-se até o subcutâneo (Figura 4). Presença de focos de material granular, parcialmente eosinofílico, junto a fibras colágenas da derme reticular, configurando "figuras em chama" (Figura 5). A imunofluorescência direta foi inespecífi-ca, com depósitos contínuos e homogêneos de IgM na zona da membrana basal e nas paredes dos vasos da derme papilar. Os exames laboratoriais revelaram leucocitose (13.800) com eosinofilia relativa e absoluta (12,9%, 1.780). A pesquisa de porfirinas na urina, FAN, anticoagulante lúpico, anticardiolipina foi negativa, e a dosagem de complemento total e frações, normal.O quadro foi resistente à terapêutica inicial com anti-histamínicos, sulfona e montelucaste sódico e só respondeu à corticoterapia oral (1mg/kg/dia, com Recebido em 26.11.2007. Aprovado pelo Conselho Editorial e aceito para publicação em 28.11.2007.

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Wells’ syndrome: a clinical and histopathologic review of seven cases

Cited by 97 publications

References 43 publications

Wells� syndrome in childhood: two case reports with review of the literature

Wells� syndrome in childhood: two case reports with review of the literature

Eosinophilic dermatitis with edema (WellsMike syndrome) possibly triggered by cooked fish in a dog

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