Wells’ syndrome associated with recurrent giardiasis

Abstract

Wells' syndrome (WS) is a rare, recurrent, inflammatory dermatosis of uncertain pathogenesis, although a hypersensitivity response to different stimuli has been postulated. Several cases in association with parasitic infections have been described. We present a patient with WS associated with recurrent giardiasis. The course of the dermatosis was strictly related to the course of the parasitic infection. Both diseases disappeared with antiparasitic treatment. To our knowledge, this association is here reported for the first time.

A case report of Wells’ syndrome in a celiac patient

“…To date, it has been associated with drugs, various viral infectious diseases, malignancies, arthropod bites, cutaneous parasitosis, and ulcerative colitis. Among parasitosis, ascariasis, toxocariasis, onchocerciasis and giardiasis have been reported to be associated with Wells' syndrome (1)(2)(3)(4). Herein, we report Wells' syndrome in a celiac disease patient with concomitant Giardia infestation.…”

The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis

“…Recurrent giardiasis has been associated to chronic eosinophilia [66], along with increased IL-5 concentrations within blood serum in humans [67]. One report described a critical role for eosinophils in the production of IgA in an IL-1β dependent manner [68].…”

Wells' syndrome associated with ulcerative colitis: a case report and literature review

“…1 A review of the literature identifi ed four case reports of gastrointestinal pathology associated with Wells' syndrome. The fi rst case was reported by Canonne et al, 4 in which they described a patient who presented with a 4-year history of recurrent skin lesions along with peripheral eosinophilia. Examination of the stool revealed Giardia intestinalis cysts.…”

“…Finally they become atrophic with spontaneous resolution. [2][3][4][5][6] Histologic changes are most characteristic for an initial intense eosinophilic infi ltrate followed by fl ame fi gures and a granulomatous reaction. 2,3,6 Peripheral blood eosinophilia occurs in approximately 50% of cases.…”