Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model

Li, Jiajia; Chen, Weiling; Wang, Jianyi; Hu, Qianwen; Sun, Zhijing; Zhang, Shuai; Liu, Sheng; Han, Xin

doi:10.1038/aps.2017.13

Cited by 17 publications

(6 citation statements)

References 38 publications

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“…Recently, studies on the anticancer effects of natural products have been conducted, and interest in natural product-derived medicines is increasing [29][30][31][32]. According to our previous report, Angelica gigas (Ag), Zingiber officinale Roscoe (Zo), and Aconitum carmichaeli (Ac) showed anticancer effects in the cell lines of several cancers, including brain, breast, prostate, colorectal, skin, and pancreatic cancer [33][34][35][36][37][38]. Furthermore, it is known that natural treatments for various inflammatory diseases and obesity have neuroprotective effects [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

JI017 Induces Cell Autophagy and Apoptosis via Elevated Levels of Reactive Oxygen Species in Human Lung Cancer Cells

Kim

Choi

et al. 2023

IJMS

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Lung cancer is one of the most common malignant tumors and a leading cause of cancer-related death in the worldwide. Various anticancer drugs, such as cisplatin and pemetrexed, have been developed for lung cancer treatment but due their drug resistance and side effects, novel treatments need to be developed. In this study, the efficacy of the natural drug JI017, which is known to have few side effects, was tested in lung cancer cells. JI017 inhibited A549, H460, and H1299 cell proliferation. JI017 induced apoptosis, regulated apoptotic molecules, and inhibited colony formation. Additionally, JI017 increased intracellular ROS generation. JI017 downregulated PI3K, AKT, and mTOR expression. JI017 increased the cytosolic accumulation of LC3. We found that JI017 promoted apoptosis through ROS-induced autophagy. Additionally, the xenograft tumor size was smaller in JI017-treated mice. We found that JI017 treatment increased MDA concentrations, decreased Ki-67 protein levels, and increased cleaved caspase-3 and LC3 levels in vivo. JI017 decreased cell proliferation and increased apoptosis by inducing autophagy signaling in H460 and H1299 lung cancer cells. Targeting JI017 and autophagy signaling could be useful in lung cancer treatment.

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Section: Introductionmentioning

confidence: 99%

JI017 Induces Cell Autophagy and Apoptosis via Elevated Levels of Reactive Oxygen Species in Human Lung Cancer Cells

Kim

Choi

et al. 2023

IJMS

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“…The Immunohistochemistry (IHC) index was determined as the average integral optical density (AIOD), calculated as the positive area multiplied by the optical density, divided by the total area (AIOD = positive area × optical density/total area). The numbers of positive cells were recorded for further analysis, following established protocols [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways

Lee,

Hsieh,

Tung

et al. 2024

Antioxidants

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Hericium erinaceus, a consumable mushroom, has shown a potential to enhance the production of neuroprotective bioactive metabolites. Traumatic brain injury (TBI) often leads to cognitive, physical, and psychosocial impairments, resulting in neuroinflammation and the loss of cortical neurons. In this research, the effects of H. erinaceus mycelium, its derivative erinacine C, along with the underlying mechanisms, were examined in terms of oxidative stress modulation and neurological improvement in a rat model of mild traumatic brain injury (mTBI). Male Sprague-Dawley rats were administered diets containing H. erinaceus mycelium and erinacine C following experimental brain injury; these supplements were continued throughout the recovery phase. The binding activity of NF-E2-related factor 2 (Nrf2) near antioxidant genes in mixed glial cells was measured by chromatin immunoprecipitation-quantitative polymerase chain reaction (ChIP-qPCR). The motor beam walking test revealed that dietary supplementation of H. erinaceus mycelium resulted in modest improvements in spatial memory while inhibiting neuron cell death and microglial activation according to brain histological examination. These findings were further corroborated by the upregulation of several antioxidant enzymes (catalase, glutathione reductase, thioredoxin reductase, and superoxide dismutase) and phospho-CAMP-response element-binding (p-CREB) levels in the mTBI model treated with H. erinaceus mycelium. Erinacine C treatment led to significantly reduced brain inflammation and normalization of mTBI-induced deficits through the modulation of the Nrf2 activation pathway and upregulated expression of numerous Nrf2-binding antioxidant genes such as catalase, thioredoxin reductase, superoxide dismutase, and brain-derived neurotrophic factor. This study demonstrates the potential of H. erinaceus mycelium and erinacine C in facilitating recovery following mTBI, including the prevention of neuronal injury and inactivation of microglia through the Nrf2-mediated antioxidant pathway in vivo.

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“…It is revealed that ZA significantly inhibits RANKL/RANK pathway to suppress micrometastasis of cancer. In addition, ZA also reduces the number and persistence of disseminated tumor cells in the bone marrow of patients with breast cancer [ 101 , 102 ], through inhibiting chemokine C-C motif ligand 5 (CCL5)/chemokine receptor (CCR5) and IL-17B/17-BR [ 103 ]. CCL5/CCR5 regulates the coupling of cancer cells and mesenchymal stromal cells [ 104 ], and IL-17B/17-BR stimulates chemokines or enhancing inflammation [ 105 ], both of them facilitate the progression and metastasis of cancer cells.…”

Section: Anticancer Effects Of Zamentioning

confidence: 99%

Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review

Wang

Fang

et al. 2020

BMC Cancer

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Zoledronic acid (ZA) is one of the most important and effective class of anti-resorptive drug available among bisphosphonate (BP), which could effectively reduce the risk of skeletal-related events, and lead to a treatment paradigm for patients with skeletal involvement from advanced cancers. However, the exact molecular mechanisms of its anticancer effects have only recently been identified. In this review, we elaborate the detail mechanisms of ZA through inhibiting osteoclasts and cancer cells, which include the inhibition of differentiation of osteoclasts via suppressing receptor activator of nuclear factor κB ligand (RANKL)/receptor activator of nuclear factor κB (RANK) pathway, non-canonical Wnt/Ca2+/calmodulin dependent protein kinase II (CaMKII) pathway, and preventing of macrophage differentiation into osteoclasts, in addition, induction of apoptosis of osteoclasts through inhibiting farnesyl pyrophosphate synthase (FPPS)-mediated mevalonate pathway, and activation of reactive oxygen species (ROS)-induced pathway. Furthermore, ZA also inhibits cancer cells proliferation, viability, motility, invasion and angiogenesis; induces cancer cell apoptosis; reverts chemoresistance and stimulates immune response; and acts in synergy with other anti-cancer drugs. In addition, some new ways for delivering ZA against cancer is introduced. We hope this review will provide more information in support of future studies of ZA in the treatment of cancers and bone cancer metastasis.

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Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model

Cited by 17 publications

References 38 publications

JI017 Induces Cell Autophagy and Apoptosis via Elevated Levels of Reactive Oxygen Species in Human Lung Cancer Cells

JI017 Induces Cell Autophagy and Apoptosis via Elevated Levels of Reactive Oxygen Species in Human Lung Cancer Cells

The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways

Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review

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