Wernicke encephalopathy following advanced caecum cancer

Li, Qiang; Wang, Fengping; Liu, Cheng; Chen, Ling; Wu, Zonghui

doi:10.17235/reed.2021.8343/2021

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…In order to prevent irreversible brain damage due to untreated Wernicke's encephalopathy, thiamin replacement therapy administered along with dextrose fluid or parenteral nutrition solutions should be considered as prophylactic treatment in hospitalized cancer patients where enteral nutrition cannot be provided for an extended period. Batori et al [5] 1995 1 Gastric cancer Subtotal gastrectomy Arai et al [6] 1997 2 Gastric cancer Total gastrectomy Shimomura et al [7] 1998 3 Gastric cancer Total gastrectomy, subtotal gastrectomy Attard et al [8] 2006 1 Benign gastric tumor** Subtotal gastrectomy Karayiannakis et al [9] 2011 1 Pancreatic cancer Pancreaticoduodenectomy Rufa et al [10] 2011 10 Pancreatic cancer, colon cancer, gallbladder cancer, gallbladder adenoma Abdominal-perineal resection, gastro-entero-anastomosis, hemicolectomy, pancreaticoduodenectomy, cholecystectomy Busani et al [11] 2014 1 Duodenal cancer Pancreaticoduodenectomy Kilinc et al [12] 2015 1* Pancreatic cancer Pancreaticoduodenectomy Wu et al [13] 2016 1* Pancreatic cancer Pancreaticoduodenectomy Restivo et al [14] 2016 19 Gastric cancer, colorectal cancer Total/distal gastrectomy, hemicolectomy, anterior resection, abdominal perineal resection Tozzo et al [15] 2017 1 Gastric cancer Subtotal gastrectomy Tsao et al [16] 2017 1* Gastric cancer Subtotal gastrectomy AbdelRazek et al [17] 2018 1 Pancreatic cancer Pancreaticoduodenectomy Kim et al [18] 2019 1 Ampulla of vater cancer Pancreaticoduodenectomy Fedeli et al [19] 2020 2 Gastric cancer, colorectal cancer Subtotal gastrectomy, anterior resection of rectum Li et al [20] 2021…”

Section: Discussionmentioning

confidence: 99%

“…The primary malignancies documented in these studies were colorectal, gastric, pancreatic, and gallbladder cancer, pelvic sarcoma, acute myelogenous leukemia, inflammatory breast carcinoma, and multiple myeloma. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] To the best of our knowledge the present case is the first to report a Wernicke's encephalopathy in a patient diagnosed with cholangiocellular carcinoma. Previous case reports of Wernicke's encephalopathy in cancer patients after gastrointestinal surgery are listed in Table 1.…”

Section: Discussionmentioning

confidence: 99%

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A case report of Wernicke Korsakoff syndrome in a patient with cholangiocellular carcinoma: An underestimated cause of encephalopathy in cancer patients

et al. 2022

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Introduction: Wernicke’s encephalopathy, a disorder caused by thiamin deficiency, is characterized by a classical triad of encephalopathy, ataxia, and ophthalmoplegia. Although alcoholism is the most common predisposing factor, it can also be associated with nonalcoholic states (hyperemesis gravidarum, intestinal obstruction, bariatric surgery, and others). This work presents a case of nonalcoholic Wernicke-Korsakoff syndrome diagnosed in a cholangiocellular carcinoma patient and literature review. Case report: A 65-year-old male patient with a history of cholangiocellular carcinoma (Klatskin tumor) was treated with radiotherapy at the operation site after Roux-en-Y hepaticojejunostomy. During follow-up, the patient developed gastric outlet obstruction and was diagnosed with peritoneal carcinomatosis after a palliative gastrojejunostomy. As the patient could not tolerate oral nutrition during hospitalization, total parenteral nutrition was administered. After 10 days of admission, the patient showed decreased response to verbal stimuli as well as bilateral horizontal nystagmus, lethargy, and disorientation. Furthermore, the patient displayed confabulation. Clinical and imaging findings were consistent with Wernicke’s encephalopathy. Therefore, treatment with intravenous thiamin replacement was initiated. The patient’s encephalopathy regressed on the second day after treatment, and he recovered the place-person-time orientation. In the following month, the abnormal imaging findings were almost entirely resolved. Conclusion: In order to prevent irreversible brain damage induced by chronic thiamin deficiency, thiamin replacement therapy with parenteral nutrition solutions should be included as a treatment for hospitalized cancer patients unable to receive enteral nutrition for a long time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case report of Wernicke Korsakoff syndrome in a patient with cholangiocellular carcinoma: An underestimated cause of encephalopathy in cancer patients

et al. 2022

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Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery

Koca,

Turna

2024

Open Medicine

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Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review

Cornea

Lata²,

Simu³

et al. 2022

Nutrients

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Wernicke encephalopathy (WE) is a well-known neurological condition caused by thiamine (vitamin B1) deficiency that occurs in both alcoholic and non-alcoholic populations. We aimed to report a case of a patient with WE who presented with dysphagia and dysphonia and later developed typical symptoms of thiamine deficiency and to conduct a systematic review of the literature on this rare presentation of WE. We searched two databases (PubMed and Scopus) and included publications up to November 2022. We found 12 cases of WE and dysphagia, aged between 12 and 81 years; swallowing problems presented at the onset in nine patients (including the current case report). Our findings suggest that thiamine deficiency should be suspected in patients with dysphagia of unknown cause, even in the absence of alcohol abuse. In contrast to most WE patients, the majority of patients included in this review presented with dysphagia at the onset of their disease, even in the absence of the classic triad of cognitive impairment, ataxia, and oculomotor abnormalities, indicating that there could be varying susceptibilities to clinical manifestations of thiamine deficiency in different brain regions.

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Wernicke encephalopathy following advanced caecum cancer

Cited by 3 publications

References 2 publications

A case report of Wernicke Korsakoff syndrome in a patient with cholangiocellular carcinoma: An underestimated cause of encephalopathy in cancer patients

A case report of Wernicke Korsakoff syndrome in a patient with cholangiocellular carcinoma: An underestimated cause of encephalopathy in cancer patients

Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery

Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review

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