Wernicke′s encephalopathy following hyperemesis gravidarum

Chandwani, Juhi; Kantor, Sandeep; Sarma, Kalpana; Albahrani, Maher J

doi:10.4103/0972-5229.128706

Cited by 26 publications

(23 citation statements)

References 10 publications

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“…The cost of care is estimated to be $47,351 per HG patient (Piwko et al, 2013). Although uncommon in contemporary practice, several maternal deaths have also been reported secondary to HG (Daaloul et al, 2012; Kantor et al, 2014; Knight et al, 2014; MacGibbon et al, 2015). These fatalities illustrate the importance of rapid diagnosis, preventative vitamin supplementation, and electrolyte monitoring and correction (MacGibbon et al, 2015).…”

Section: Hyperemesis Gravidarummentioning

confidence: 99%

Nausea and vomiting of pregnancy - What's new?

Bustos

Venkataramanan²,

Caritis

2017

Autonomic Neuroscience

118

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Nausea and vomiting of pregnancy (NVP) is one of the most common disorders of pregnancy. The symptoms occur predominantly during the first trimester, although in a subgroup of patients they can continue throughout the entire pregnancy and can affect the woman’s quality of life. A small percentage of women develop a severe form of NVP called hyperemesis gravidarum (HG) that if left untreated may lead to significant maternal morbidity and adverse birth outcomes. Overall, the morbidity in pregnant women with NVP is significant, although it tends to be underestimated. The pathogenesis of NVP remains unclear, but there is consensus that the disorder is multifactorial and that various genetic, endocrine and infectious factors may be involved. The treatment of NVP can be challenging as the optimal targets for therapy are not known. Currently, the therapy used depends on the severity of the disorder and it is focused on improving the symptoms while minimizing risks to mother and fetus. Therapies range from dietary changes, pharmacologic treatment or hospitalization with intravenous fluid replacement and nutrition therapy. The aims of this review are 1) to provide an overview of NVP, 2) to present possible links between the most important factors associated with the pathogenesis of NVP and 3) to discuss the effectiveness and safety of the pharmacologic and non-pharmacologic options available to treat this disorder.

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Section: Hyperemesis Gravidarummentioning

confidence: 99%

Nausea and vomiting of pregnancy - What's new?

Bustos

Venkataramanan²,

Caritis

2017

Autonomic Neuroscience

118

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“…Острые дефицитарные формы АБ [17]. Методом выбора при диагностике ЭВ является магнитно-резонансная томография (МРТ) головы, чувствительность которой составляет 93% [19]. Патогномоничными для ЭВ считаются изменения в области перивентрикулярных отделов промежуточного мозга, ствола мозга, участки мозга вокруг желудочка, сильвиева водопровода и IV желудочка [20].…”

Section: о с т р ы е и х р о н и ч е с к и е ф о р м ы п о р а ж е н unclassified

Nervous system injury in alcoholic disease

Zinovyeva

Vashchenko

Mozgovaya

et al. 2019

RJTAO

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The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

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“…However in non alcoholics the prevalence varies from 0.04% to 0.13%. 1 It is a potentially reversible condition however if untreated could be fatal. Wernicke-Korsakoff syndrome is a chronic neurological sequel of Wernicke encephalopathy (WE).…”

Section: Introductionmentioning

confidence: 99%

Hyperemesis gravidarum causing Wernicke–Korsakoff syndrome: A rare complication

Mishra

Verneker

2019

J of Obstet and Gynaecol

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Wernicke-Korsakoff syndrome (WKS) is a rare neurological disorder due to severe thiamine deficiency. It is most prevalent among alcoholics. However in nonalcoholics the prevalence varies from 0.04% to 0.13%. We report a case of WKS due to hyperemesis gravidarum. Primigravida patient with 16 weeks pregnancy with continuous vomiting for 1 month developed Wernicke's encephalopathy which progressed to Korsakoff psychosis. Patient was conservatively managed till term with appropriate thiamine replacement and antipsychotics. She developed oligohydramnios with late intrauterine growth retardation. Elective cesarean was done at 36 weeks. Female child with birth weight of 2.2 kg was born. Hyperemesis is a rare cause of WKS. This patient was inappropriately treated with dextrose and antiemetic without proper thiamine replacement. This case report highlights the importance of thiamine replacement and proper management of hyperemesis gravidarum with a scientific approach to prevent fatal complications like WKS.

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Wernicke′s encephalopathy following hyperemesis gravidarum

Cited by 26 publications

References 10 publications

Nausea and vomiting of pregnancy - What's new?

Nausea and vomiting of pregnancy - What's new?

Nervous system injury in alcoholic disease

Hyperemesis gravidarum causing Wernicke–Korsakoff syndrome: A rare complication

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