Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Oudman, Erik; Wijnia, Jan W.; Oey, Misha J.; Dam, Mirjam van; Painter, Rebecca C.; Postma, Albert

doi:10.1016/j.ejogrb.2019.03.006

Cited by 91 publications

(148 citation statements)

References 107 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…However, consequently mother showed considerable ement and was discharged in stable condition with low moods. The sequential occurrence of intractable HG, WE and WKS is reported in the literature and multimodal approach including use of steroids tends to treat HG complicated by WE WKS [5,7,15,25]. Presumably, there might be multiple causes of fetal demise in this patient including subtherapeutic or very high doses of thymine, comorbid diabetes mellitus and hypertension, uncorrected electrolyte imbalance, iamine, and no use of steroid therapy.…”

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 81%

“…Second, pregnant mothers should immediately consult hospital emergency services or the nearest PHC when the fetal ents become feeble in order to prevent the early or late IUFD as happened in this case. However, in addition to other severe psychophysical burden, 50% pregnancies with HG and WE result in either abortion or early/late fetal demise, and 3% maternal mortali deteriorating pregnancies [7,[24][25][26].…”

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 99%

“…The outcome of pregnancy in this patient was early IUFD, and mother was mildly depressed with low moods and anxiety. The role of anxiety and depression in intractable HG is controversial and discussed extensively in the literature [7,25,31,32]; however most studies reported psychological disturbances being the sequelae of HG. Case 3 presented with features of HG and WE and later developed refractory hyponatremia associated with possible CPM consistent with other studies [20,22,33].…”

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 99%

“…HG characterized by pernicious nausea and vomiting, dehydration, electrolyte and fluid imbalance, weight loss, and ketonuria and necessitates hospital admission [2,3]. Hundreds of cases and studies have reported HG, WE, WKS and central pontine myelinolysis (CPM) in the literature with marked variability in clinical picture, laboratory findings, response to treatment and fetal, offspring and maternal outcome [5][6][7][8][9][10]. The etiology of HG is multifactorial and its pathophysiology is not yet fully understood [5][6][7]11].…”

Section: Introductionmentioning

confidence: 99%

“…Hundreds of cases and studies have reported HG, WE, WKS and central pontine myelinolysis (CPM) in the literature with marked variability in clinical picture, laboratory findings, response to treatment and fetal, offspring and maternal outcome [5][6][7][8][9][10]. The etiology of HG is multifactorial and its pathophysiology is not yet fully understood [5][6][7]11]. Furthermore, HG is reported to be aggravated by diverse cooccurring systematic diseases, surgical complications, WE, KS, and WKS, and needs multimodal approach including surgical interventions [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Hyperemesis Gravidarum, Wernicke’s Encephalopathy and Korsakoff Syndrome Looked through the Lens of Three Cases, Paper II

Salahuddin¹,

Dutta²,

Qureshi

2019

JAMMR

View full text Add to dashboard Cite

Objective: Pregnancy a normal physiological condition is worsened by morning sickness, nausea and vomiting of pregnancy, hyperemesis gravidarum, Wernicke’s encephalopathy and Korsakoff syndrome in vulnerable women with gestation. This report of three cases described hyperemesis gravidarum, Wernicke’s encephalopathy and Korsakoff syndrome in the worsening pregnancies. Methods: Prospective collection of data concerning three pregnant patients seen in Dubai Health Care City, Dubai, United Arab Emirates. Results: All three patients were admitted to the hospital with manifestations of HG and WE and one of them showed additional features of Korsakoff syndrome. One patient developed intractable hyponatremia and central pontine myelinolysis. Two patients developed abortion while one patient's pregnancy ended with successful delivery with living infant. All patients were managed with thiamine, antiemetics, parenteral fluids and electrolytes and one patients required steroid therapy. Conclusion: The findings of these cases are compatible with international literature on HG and its sequential syndromes. This study may enhance awareness of HG, WE and KS and also fill the knowledge gap of professionals providing services to women with worsening health during pregnancy in Arabian Gulf countries.

show abstract

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 81%

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 99%

Section: Mri Findings In Wernicke's Encephalopathymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hyperemesis Gravidarum, Wernicke’s Encephalopathy and Korsakoff Syndrome Looked through the Lens of Three Cases, Paper II

Salahuddin¹,

Dutta²,

Qureshi

2019

JAMMR

View full text Add to dashboard Cite

show abstract

Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases

et al. 2021

View full text Add to dashboard Cite

Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing?

Erick

2022

Nut in Clin Prac

View full text Add to dashboard Cite

Hyperemesis gravidarum (HG), or the severe nausea and vomiting of pregnancy, is one of the most dreaded complications of gestation, affecting between 1.5% and 3.0% of pregnant women. From the late 1800s to the mid-1980s, the etiology was frequently cited to have psychological and/or-laterperhaps hormonal origins, which have numbered at least 10. Current research has unearthed a genetic basis for HG that implicates growth differentiation factor 15, insulin-like growth factor binding protein 7, and hormone receptors (namely, glial cell line-derived neurogenic factor family receptor alpha-like and the progesterone receptor). Whatever the origins of this disease, it has caused immeasurable physiological and psychological damage to women, their fetuses, and their families. The psychological trauma includes a high rate of suicidal ideation as well as posttraumatic stress disorder. Whereas the healthcare costs are substantial for the mother with HG, the lifetime costs to the neonate include that which accompanies reduced employment earnings related to cognitive compromise. Another devastating outcome of severe HG can be Wernicke's encephalopathy (WE), which has a high fetal and maternal mortality rate. Our study explored 18 current reports of HG and WE. We highlighted additional presenting features we believe also accompany, and sometimes replace, the classically taught triad components of WE: ataxia, confabulation, and nystagmus. We agree with the conclusion made by Sheehan and Ironside in 1939 that thiamin alone may not reverse WE, and we offer possible explanations. Lastly, we offer suggestions for remediation.

show abstract

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Cited by 91 publications

References 107 publications

Hyperemesis Gravidarum, Wernicke’s Encephalopathy and Korsakoff Syndrome Looked through the Lens of Three Cases, Paper II

Hyperemesis Gravidarum, Wernicke’s Encephalopathy and Korsakoff Syndrome Looked through the Lens of Three Cases, Paper II

Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases

Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing?

Contact Info

Product

Resources

About