Wernicke's encephalopathy induced by magnesium depletion

McLEAN, J F; Manchip, Simon

doi:10.1016/s0140-6736(99)00182-8

Cited by 49 publications

(32 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In an ICU setting, the use of continuous renal replacement therapies or diuretics (eg, infusion of furosemide) exacerbates TD for an increased loss 4 , 12 . Body cells are unable to use thiamine for metabolism in the absence of magnesium, as it is needed for the conversion of thiamine into thiamine pyrophosphate 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Rapid Reversal of Severe Lactic Acidosis After Thiamine Administration in Critically Ill Adults

et al. 2014

View full text Add to dashboard Cite

The 3 cases demonstrated the rapidity of the reversal of severe thiamine deficiency, achieved by appropriate replacement in different hospitalized patients. The regression of clinical and biochemical disorders requires a prompt diagnosis and treatment based on the IV administration of thiamine and magnesium sulfate. In hospitalized patients at risk, thiamine deficiency is prevented by the integration of thiamine supplementation into PN and other forms of nutrition support.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid Reversal of Severe Lactic Acidosis After Thiamine Administration in Critically Ill Adults

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Transketolase requires TPP and magnesium as a cofactor [19]. Case studies suggest that hypomagnesaemia is a potential cause of occasional non‐response to thiamine replacement in some patients with WKS [19–21]. Animal studies confirm that magnesium deficiency interferes with the response to thiamine replacement, and the effect of magnesium deficiency appears to be due to interference with activation to transketolase [18].…”

Section: Discussionmentioning

confidence: 99%

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Dingwall

Delima

Gent

et al. 2015

Drug and Alcohol Review

View full text Add to dashboard Cite

show abstract

“…Despite massive doses of thiamin administered intravenously, the symptoms of thiamin deficiency could not be relieved until correction of the magnesium deficiency (18). Wernicke encephalopathy, a well known result of thiamin deficiency, has been reported as being induced by magnesium deficiency (19). …”

Section: Discussionmentioning

confidence: 99%

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

Lonsdale

2006

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effect (TPPE), indicating intracellular cofactor deficiency, usually improves with thiamin administration. Biochemical correction of the abnormality is, however, invariably dependent on the provision of other NCN, especially magnesium. In two patients reported here, this correction required several infusions containing magnesium and other NCN administered intravenously. In a third patient, hemoconcentration associated with an abnormal TPPE was normalized after administration of nutrients that included thiamin and magnesium.

show abstract

Wernicke's encephalopathy induced by magnesium depletion

Cited by 49 publications

References 3 publications

Rapid Reversal of Severe Lactic Acidosis After Thiamine Administration in Critically Ill Adults

Rapid Reversal of Severe Lactic Acidosis After Thiamine Administration in Critically Ill Adults

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

Contact Info

Product

Resources

About