Wernicke's Encephalopathy

Lopez, Raul I.

doi:10.1001/archneur.1968.00470330038003

Cited by 55 publications

(2 citation statements)

References 28 publications

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“…Ocular abnormalities are less common, but among them the most frequent are nystagmus, lateral rectus palsy and a degree of gaze paresis. Swelling of the optic discs and retinal haemorrhage are rare, but have been reported 20–22 …”

Section: Discussionmentioning

confidence: 99%

Wernicke's encephalopathy in association with complicated acute pancreatitis and morbid obesity

Winslet

Aitchison

1990

Int J Clinical Practice

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Section: Discussionmentioning

confidence: 99%

Wernicke's encephalopathy in association with complicated acute pancreatitis and morbid obesity

Winslet

Aitchison

1990

Int J Clinical Practice

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“…This encephalopathy usually occurs in chronic alcoholic patients, but it has also been reported in other patients, including those with some chronic gastrointestinal diseases, gastric carcinoma [2], hyperemesis gravidarum [3], hemodialysis[4], during the postoperative period following gastrointestinal tract surgery [5], or in patients who received intravenous hyperalimentation (IVH) [6]. Wernicke’s encephalopathy is a potentially curable disease if vitamin B 1 is administered intravenously during the early stage of the disease, but it may cause significant neurological deficits or have a fatal outcome if therapy is delayed.…”

Section: Introductionmentioning

confidence: 99%

‘Iatrogenic’ Wernicke’s Encephalopathy in Japan

Shikata¹,

Mizutani²,

Kokubun³

et al. 2000

Eur Neurol

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‘Iatrogenic’ Wernicke’s encephalopathy has appeared to occur more frequently in Japan, probably induced by the change of our Japanese national health insurance policy in 1992. We report 4 nonalcoholic patients with such Wernicke’s encephalopathy, which occurred during the early postoperative oral food intake period following intravenous nutrition without vitamin supplements. We analyzed the medical records of 4 patients, 3 men and 1 woman, aged between 55 and 71 years, who were admitted to our hospital between 1992 and 1995. Three patients underwent gastrointestinal surgery and 1 suffered chronic pyothorax. We diagnosed our patients as having Wernicke’s encephalopathy based on typical neurological abnormalities, in addition to typical cranial magnetic resonance image findings, low serum vitamin B₁ levels, or both. Although all of the patients were treated with vitamin B₁ and showed some improvement, 1 patient developed Korsakoff syndrome, 2 made incomplete neurological recovery, and 1 died. We speculated that the body vitamin B₁ stores had been decreasing in our patients who did not receive any vitamin supplements during intravenous hyperalimentation or hydration. Subsequent administration of high calorie and high carbohydrate oral diets increased the demand for vitamin B₁, further depleting the vitamin stores, thereby causing ‘iatrogenic’ Wernicke’s encephalopathy. The change of our national health insurance policy in 1992 discouraged the routine administration of vitamins, probably causing Wernicke’s encephalopathy in our patients.

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Transketolase Activity in Uremia

Lonergan¹

1970

Arch Intern Med

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Erythrocyte transketolase activity (ETKA) was determined in ten uremics undergoing long-term hemodialysis and in four patients treated with Giordano\x=req-\ Giovanetti diet therapy. Transketolase (BUN 12 mg/100 ml) was subjected to hemodialysis for four hours in the Kolff twin-coil dialy¬ zer and then tested both for changes in its own erythrocyte TKA and for any effect of the dialyzed plasma on TKA when in¬ cubated with other normal red blood cell hemolysates. Next, 1 liter aliquots were obtained from the dialysate resulting from six hours of dialysis of uremie patients. These samples were concen¬ trated by flash evaporation and lyophilization to a dry powder which was redissolved in 20 ml of distilled water, passed through an ion and cation retardation resin and then separated by selective fil¬ tration through ultrafiltration membranes into three fractions of different molecular weight (fraction 1:<501 molecular weight; fraction 2: 501-1,000 mol wt; fraction 3: 1,001-10,000 mol wt). The fractions were subsequently incubated with normal red

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Wernicke's Encephalopathy

Cited by 55 publications

References 28 publications

Wernicke's encephalopathy in association with complicated acute pancreatitis and morbid obesity

Wernicke's encephalopathy in association with complicated acute pancreatitis and morbid obesity

‘Iatrogenic’ Wernicke’s Encephalopathy in Japan

Transketolase Activity in Uremia

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