Wert und Akzeptanz einer Alzheimer-Risikodiagnostik

Bartzsch, O.; Gertheiss, Jan; Calabrese, Pasquale

doi:10.1007/s00115-015-4402-x

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Frequently mentioned reasons for desiring this information, e.g., planning for the future and relief from uncertainty, were also stated by participants in our study [ 31 ]. The increase in health state utility value found for a low predicted risk on progression to dementia is in line with a study by Bartzsch et al [ 32 ], that shows an improvement in well-being and a reduction of fears and worries in participants with a reduced risk for Alzheimer’s disease. In contrast to our findings, they found neither a significant deterioration of the mental situation nor an increase of fears and worries among participants with an elevated risk.…”

Section: Discussionsupporting

confidence: 90%

Prognostic Information on Progression to Dementia: Quantification of the Impact on Quality of Life

Vermeulen,

Roudijk,

Govers

et al. 2024

Journal of Alzheimer’s Disease

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Background: The increasing interest in early identification of people at risk of developing dementia, has led to the development of numerous models aimed at estimating the likelihood of progression from mild cognitive impairment (MCI) to dementia. It is important to study both the need for and possible outcomes related with such prediction models, including the impact of risk predictions on perceived quality of life (QoL). Objective: This study aimed to quantify the impact that receiving a risk prediction on progression from MCI to dementia has on QoL. Methods: A Discrete Choice Experiment (DCE) and Time Trade Off (TTO) study were performed. Participants completed choice tasks related to dementia prognosis while imagining having MCI. We collected DCE data by an online survey, and TTO data via videoconferencing interviews. DCE data were analyzed using a mixed multinomial logit model and were anchored to a health state utility scale using mean observed TTO valuations. Results: 296 people participated in the DCE and 42 in the TTO. Moderate and high predicted dementia risks were associated with decrements in utility (–0.05 and –0.18 respectively), compared to no prognostic information. Low predicted risk was associated with an increase in utility (0.06), as well as the availability of medication or lifestyle interventions (0.05 and 0.13 respectively). Conclusions: This study shows a significant impact of dementia risk predictions on QoL and highlights the importance of caution when sharing information about expected MCI disease courses.

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Section: Discussionsupporting

confidence: 90%

Prognostic Information on Progression to Dementia: Quantification of the Impact on Quality of Life

Vermeulen,

Roudijk,

Govers

et al. 2024

Journal of Alzheimer’s Disease

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“…The interviewees thus identified a core problem of such prevention studies with currently existing inconsistent data. For example, in a prospective study of adult participants (Bartzsch et al, 2015; N = 106), the authors used MRI-based hippocampal volumetry to stratify Alzheimer’s risk. They then dichotomized the outcome into increased and decreased risk.…”

Section: Discussionmentioning

confidence: 99%

Attitudes and Viewpoints Toward Prevention Trials in Alzheimer’s Disease

et al. 2024

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Alzheimer’s disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used semistructured individual interviews to interview uninvolved persons ( n = 10), relatives of Alzheimer’s patients ( n = 10), and patients with mild cognitive impairment ( n = 5) and analyzed the interviews using qualitative content analysis according to Mayring. We discovered various factors to be positive motivations for participation; the most significant inhibiting factor was concern about negative psychological effects. These motivations and concerns should be specifically addressed in the study design of AD prevention trials. The fears and concerns expressed highlight the importance of a good methodological and ethical framework to increase participant acceptance.

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“…Eine weitere Veränderung ist, bezogen auf das Lebensalter, eine signifikante Verkleinerung des Hippocampus. Sie kann relativ zuverlässig mittels einer MRT-basierten Volumetrie ermittelt werden [7]. Diese bildgebenden Verfahren erlauben in Kombination mit dominant, dass nahezu alle medikamentösen Hoffnungsträger der Pharmaindustrie nur mit dem einen Ziel entwickelt wurden: das Alzheimer-Toxin im Gehirn der Betroffenen auf die eine oder andere Art zu eliminieren.…”

Section: Ein Dogma Verhindert Den Durchbruch In Prävention Und Therapieunclassified

Lebensweise und Alzheimer

Nehls¹

2017

EHK

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ZusammenfassungAlzheimer ist eine Mangelkrankheit, verursacht durch Diskrepanzen zwischen unseren natürlichen Bedürfnissen und Folgen der heutigen Lebensweise: Chronischer Stress, ungesunde Ernährung, Mangel an Mikronährstoffen, Tiefschlaf, Bewegung, sozialen Aktivitäten sowie Verlust des Lebenssinns. Basierend auf einer Allgemeinen Theorie der Alzheimer-Entstehung (Unified Theory of Alzheimer‘s Disease, UTAD) beginnt die Erkrankung mit der gestörten Neubildung von Nervenzellen (Neurogenese) im hippocampalen Zentrum für das autobiografische Erinnern. Die mangelhafte adulte Neurogenese führt zunächst zu einem chronisch erhöhten Level an Stresshormonen, kurz- bis mittelfristig zu Depression und letztendlich zu den für Alzheimer typischen neuropathologischen und kognitiven Veränderungen. Durch gezieltes Beheben der individuellen Mängel (der kausalen Risikofaktoren) im Rahmen einer systembiologischen Intervention, lässt sich Alzheimer jedoch nicht nur vermeiden, im Frühstadium der Erkrankung ist der geistige Abbau sogar noch umkehrbar.

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Wert und Akzeptanz einer Alzheimer-Risikodiagnostik

Abstract: An MRI-based risk assessment is beneficial to the patient’s quality of life and as a low threshold approach may induce more individuals with concerns to take advantage of an early diagnosis of Alzheimer’s disease.

Cited by 4 publications

References 14 publications

Prognostic Information on Progression to Dementia: Quantification of the Impact on Quality of Life

Prognostic Information on Progression to Dementia: Quantification of the Impact on Quality of Life

Attitudes and Viewpoints Toward Prevention Trials in Alzheimer’s Disease

Lebensweise und Alzheimer

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