Wertigkeit der Computertomographie bei der Stadieneinteilung primärer Lymphknotenneoplasien

Lackner, K.; Brecht, G; Janson, R; Scherholz, K; Lützeler, A; Thurn, P

doi:10.1055/s-2008-1056518

Cited by 38 publications

(11 citation statements)

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“…Our results corresponded well with those of previous studies, which suggested an upper normal level of 314.5 cm 3 for the splenic volume (8) and for a splenic index of 480 cm 3 (1026). Our results showed good agreement with the results of a previous study by Strijk et al (11) who reported diagnostic accuracy of 91% using the criterion of the splenic index > 480 mL as indicative of splenic involvement in HD.…”

Section: Discussionsupporting

confidence: 93%

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Diffuse Infiltrative Splenic Lymphoma: Diagnostic Efficacy of Arterial-Phase CT

et al. 2016

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ObjectiveTo evaluate the diagnostic performance of obliteration of normal heterogeneous enhancement of the spleen (ONHES) on arterial phase (AP) computed tomography (CT) images in diffuse infiltrative splenic lymphoma (DISL).Materials and MethodsOne hundred and thirty-six patients with lymphoma who had undergone two-phase (arterial and portal venous) abdominal CT were included in this study. We retrospectively evaluated the diagnostic performance of ONHES on AP CT in diagnosing DISL. Two observers evaluated ONHES on AP CT using the 5-point confidence level and assessed the presence or absence of subjective splenomegaly on axial CT images. Another two observers measured the splenic index as proposed by objective CT criteria. Statistical analysis included interobserver agreement and diagnostic performance of CT findings.ResultsEleven of the 136 patients with lymphoma had DISL. The area under the receiver operating characteristic curve of ONHES (0.948 for observer 1 and 0.922 for observer 2) was superior to that of the splenic index (0.872 for observer 3 and 0.877 for observer 4), but the difference was not statistically significant (p > 0.05). The diagnostic performance of ONHES in conjunction with subjective splenomegaly showed higher diagnostic performance, as compared with subjective splenomegaly alone (accuracy: 100% and 85.3% for observer 1, 98.5% and 87.5% for observer 2; positive predictive value: 100% and 35.5% for observer 1, 90.9% and 39.3% for observer 2, respectively).ConclusionObliteration of normal heterogeneous enhancement of the spleen in conjunction with subjective splenomegaly can improve the diagnostic performance for DISL. Our results suggest that ONHES on AP CT images could be useful as an adjunctive diagnostic indicator of DISL in patients with lymphoma.

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Section: Discussionsupporting

confidence: 93%

“…They were requested to measure splenic width, thickness, and length for splenic index obtained by multiplying splenic width, thickness, and length, as previously described (1011). Maximal width and thickness at the splenic hilum were measured on axial images.…”

Section: Methodsmentioning

confidence: 99%

Diffuse Infiltrative Splenic Lymphoma: Diagnostic Efficacy of Arterial-Phase CT

et al. 2016

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“…5 5~ splenic index (16). Thus an index of 480 as upper limit for normal size (13) corresponds to a weight of 265 g. Several other studies revealed that a splenic weight of more than 500 g consistently implied splenic involvement (8,10,17). It was calculated that weight determination using a weight of 500 g as threshold value would result, for the present series, in an accuracy of 77 per cent, a specificity of 100 per cent and a sensitivity of 72 per cent.…”

Section: Discussionmentioning

confidence: 81%

The Spleen in Non-Hodgkin Lymphoma

Strijk¹,

Boetes²,

Bogman³

et al. 1987

Acta Radiol

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“…Organ involvement was noted, and spleen size was calculated in retrospect using the splenic index. The splenic index (14,24) is calculated by multiplying spleen length, width, and thickness. Spleen length is the sum of all slice thicknesses (and intervals if used) on which the spleen is seen.…”

Section: Resultsmentioning

confidence: 99%

“…Spleen width and thickness are the largest (straight) organ diameters from anterior to posterior border, and from internal to external surface, respectively. According to previous studies (14), an index of 480is used as the upper limit of normal. By definition, a higher index indicates splenomegaly, and may suggest histologic involvement with lymphoma (23,24).…”

Section: Resultsmentioning

confidence: 99%

Lymphography and Abdominal Computed Tomography in the Staging of Non-Hodgkin Lymphoma

Strijk

1987

Acta Radiol

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Ninety-one patients with non-Hodgkin lymphoma (NHL) were subjected to computed tomography (CT) and lymphography. Both examinations agreed in 74 patients (81%) with regard to the infradiaphragmatic lymph nodes. In patients undergoing CT prior to lymphography, the concordance amounted to 75 per cent. When lymphography was the initial examination, the concordance amounted to 86 per cent. Lymphography was abnormal in 30 per cent of the patients with a normal CT scan and in 93 per cent of those with an abnormal CT scan as the first examination. CT was abnormal in 4 per cent of patients with a normallymphogram and in 84 per cent of those with an abnormal lymphogram as the first examination. CT did not detect mesenteric or retrocrural lymph node enlargement in the absence of retroperitoneal lymph node involvement. Eleven patients had extranodal manifestations of the disease (excluding liver and spleen), and 3 were detected primarily with CT. Lymphography is the most complete examination for the infradiaphragmatic lymph nodes for staging purposes. Although CT outlined the disease better, it changed the lymphographic diagnosis in only 2 per cent of the patients. Lymphography modified the CT stage in 15 per cent of the patients. When abdominal CT is performed first, in staging patients with NHL, lymphography will only yield additional information when CT is normal or equivocal.

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Wertigkeit der Computertomographie bei der Stadieneinteilung primärer Lymphknotenneoplasien

Cited by 38 publications

References 0 publications

Diffuse Infiltrative Splenic Lymphoma: Diagnostic Efficacy of Arterial-Phase CT

Diffuse Infiltrative Splenic Lymphoma: Diagnostic Efficacy of Arterial-Phase CT

The Spleen in Non-Hodgkin Lymphoma

Lymphography and Abdominal Computed Tomography in the Staging of Non-Hodgkin Lymphoma

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