2020
DOI: 10.1016/j.jcmgh.2019.09.009
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“Western Diet”-Induced Adipose Inflammation Requires a Complex Gut Microbiota

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Cited by 48 publications
(34 citation statements)
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References 39 publications
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“…Moreover, both STZ- and WSD-induced hyperglycemia was itself partially ameliorated by antibiotics. 36 Considering these observations, together with IL22’s ability to protect mucosal surfaces, including by driving expression of antimicrobial peptides, suggests that a portion of inulin’s ability to ameliorate diabetes may reflect its ability to help maintain a beneficial host-microbiota relationship, both by restoring microbiota density and by preventing detrimental changes in microbiota composition.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, both STZ- and WSD-induced hyperglycemia was itself partially ameliorated by antibiotics. 36 Considering these observations, together with IL22’s ability to protect mucosal surfaces, including by driving expression of antimicrobial peptides, suggests that a portion of inulin’s ability to ameliorate diabetes may reflect its ability to help maintain a beneficial host-microbiota relationship, both by restoring microbiota density and by preventing detrimental changes in microbiota composition.…”
Section: Discussionmentioning
confidence: 99%
“…The cell sediment was subjected to red cell lysis using Pharmlyse (BD) and after washing was ready for staining. Hepatocytes, adipose tissue, gut IELs, and LPLs were prepared as described previously [ 81 , 82 , 83 , 84 ]. Single cell suspensions were stained directly using combinations of the monoclonal antibodies listed in Table 1 .…”
Section: Methodsmentioning
confidence: 99%
“…This imbalance could be due to the gain or loss of community members or changes in the relative abundance of microbes. In addition to obesity [ 27 ], metabolic syndrome [ 28 ], and type 2 diabetes [ 29 ], evidence suggest that diet can also induce dysbiosis [ 30 ], which is often associated with an increase in inflammation [ 31 , 32 ].…”
Section: Microbiota and Dysbiosismentioning
confidence: 99%