Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice

Gabriel, Michael; Nikou, Maria; Akinola, Oluwole Busayo; Pollak, Daniela D.; Sideromenos, Spyridon

doi:10.1016/j.bbr.2019.112419

Cited by 13 publications

(14 citation statements)

References 58 publications

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“…In another study, high‐fat, high‐sugar Western diet‐induced obesity, the administration of 6‐shogaol assisted in the reversion of behavioral disturbances in mice (Gabriel et al, 2020). Thus, these positive effects of 6‐shogaol may be related beyond the anti‐inflammatory and antioxidant role, to the increase of the expression of nerve growth factor (NGF) and synaptic molecules in the brain (Talebi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Rosa

Medeiros

Oliveira

et al. 2021

Intl J of Devlp Neuroscience

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Objective 6‐Shogaol, bioactive compound of Zingiber officinale Roscoe, has anti‐inflammatory, antioxidant, and neuroprotective properties. The objective of the present study was to verify the effect of 6‐shogaol on behavioral parameters in a preclinical model based on a maternal immune activation (MIA) by lipopolysaccharide (LPS). Methodology Twelve pregnant Wistar rats received 100‐μg/kg LPS or saline solution on gestational day (GD) 9.5. Male offspring participated in the study and in the postnatal day (PND) 30 and 55 were supplemented with 6‐shogaol or saline solution, by gavage at a dose of 10 mg/kg/day, orally for 5 days. In the PND 35 and 60 was performed the behavioral tests: grooming, crossing, and rearing that evaluated repetitive movements, anxiety, and interest in the new, respectively, and the inhibitory avoidance test that evaluated short‐term (STM) and long‐term memory (LTM). Result Prenatal exposure to LPS increased the grooming and crossing episodes at different ages and reduced rearing episodes in PND 37. Treatment with 6‐shogaol reversed these parameters. In the inhibitory avoidance test, an improvement of memory was identified with 6‐shogaol in the STM and LTM at both ages comparing training and test session of treated groups and between groups. Conclusion Administration of 6‐shogaol reverses the stereotypy, exploratory behavior, and memory impairment in prenatal LPS‐exposed offspring, acting as a promising therapeutic component against brain disorders associated with the process of MIA.

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Section: Discussionmentioning

confidence: 99%

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Rosa

Medeiros

Oliveira

et al. 2021

Intl J of Devlp Neuroscience

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“…This diet may cause metabolic syndromes and diseases and can increase the chances of AD development. A recent study by Gabriel et al [112] stated that chronic exposure of a high-fat, high-sugar Western diet to C57BL/6N mice significantly contributed to obesity and memory impairment. These dietary patterns increase the abundance of Flavobacterium, Runella, and Flectobacillus that can activate inflammatory responses by regulating IL-1β and the NF-κB pathways [113].…”

Section: Diet and Food Componentsmentioning

confidence: 99%

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

et al. 2021

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The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may disturb intestinal permeability and the blood–brain barrier. In addition, it can promote the hallmarks of AD, such as oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, and ultimately the causation of neural death. Poor dietary habits and aging, along with inflammatory responses due to dysbiosis, may contribute to the pathogenesis of AD. Thus, GM modulation through diet, probiotics, or fecal microbiota transplantation could represent potential therapeutics in AD. In this review, we discuss the role of GM dysbiosis in AD and potential therapeutic strategies to modulate GM in AD.

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“…The rotarod test was performed as previously described. 80 The latency to fall from the rotarod was automatically recorded (MedAssociates Inc., St. Albans, USA). Briefly, mice were first habituated to the rotating drum, and the speed of the drum was gradually increased from 4 to 40 rounds per min.…”

Section: Methodsmentioning

confidence: 99%

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain

et al. 2021

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The rising opioid crisis has become a worldwide societal and public health burden, resulting from the abuse of prescription opioids. Targeting the κ-opioid receptor (KOR) in the periphery has emerged as a powerful approach to develop novel pain medications without central side effects. Inspired by the traditional use of sunflower ( Helianthus annuus ) preparations for analgesic purposes, we developed novel stabilized KOR ligands (termed as helianorphins) by incorporating different dynorphin A sequence fragments into a cyclic sunflower peptide scaffold. As a result, helianorphin-19 selectively bound to and fully activated the KOR with nanomolar potency. Importantly, helianorphin-19 exhibited strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain, without inducing unwanted central effects on motor coordination/sedation. Our study provides a proof of principle that cyclic peptides from plants may be used as templates to develop potent and stable peptide analgesics applicable via enteric administration by targeting the peripheral KOR for the treatment of chronic abdominal pain.

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Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice

Cited by 13 publications

References 58 publications

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain

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