Western lifestyle and immunopathology of multiple sclerosis

Matveeva, Olga; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.; Linker, Ralf A.; Haghikia, Aiden; Kleinewietfeld, Markus

doi:10.1111/nyas.13583

Cited by 46 publications

(29 citation statements)

References 188 publications

(358 reference statements)

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“…Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative demyelinating disease of the central nervous system defined by a wide range of symptoms and signs that disrupt physical, cognitive, emotional, and social functioning.MS affects 2.6 women for every man with the condition [7,8], while it has been estimated that at least 2.3 million individuals worldwide suffer from the disease [9]. MS is among the most common causes of neurological disability in young adults [10,9]. The exact aetiology or causes of the disease still remains unknown, however, various traditional and non-traditional factors have been proposed as contributors such as genetic, environmental and immunological [11,10].…”

Section: Introductionmentioning

confidence: 99%

“…MS is among the most common causes of neurological disability in young adults [10,9]. The exact aetiology or causes of the disease still remains unknown, however, various traditional and non-traditional factors have been proposed as contributors such as genetic, environmental and immunological [11,10]. What is more evident is the pathophysiology of MS which is characterized by chronic inflammation, disruption of the blood-brain barrier and immune cell infiltration into the CNS.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Abnormalities in Multiple Sclerosis

Sakkas

Giannaki

Karatzaferi

et al. 2019

Curr Treat Options Neurol

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Purpose of review: This review summarizes the most well documented sleep disorders seen in patients with Multiple Sclerosis (MS), with a special focus on the impact on quality of life. Recent findings: Sleep abnormalities in patients with MS are a multifactorial and relatively complex issue affecting approximately 60% of the patients while the pathophysiology of these symptoms is not fully understood. Circadian rhythm disorders and increased levels of Pro-inflammatory Cytokines have been recognized as potential players in affecting sleep homeostasis in MS patients. Medication related side effects such as in immunotherapy and other factors such as lesion load can contribute to the disruption of normal sleep patterns. Summary: Most frequently encountered sleep disorders are insomnia, sleep-related movement disorders, sleeprelated breathing disorders and circadian rhythm disorders affecting both adults and paediatric MS populations. Aetiology still remains unknown with treatment options focusing on behavioural cognitive therapy, life style modification including improvement in sleep hygiene as well as melatonin supplementation. Given MS prevalence is still rising affecting millions of people, more personalized medicine applications should possibly form the key approach for improving patients' quality of life and quality years.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sleep Abnormalities in Multiple Sclerosis

Sakkas

Giannaki

Karatzaferi

et al. 2019

Curr Treat Options Neurol

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“…Flavonoids are a family of phenolic substances sharing the same backbone structure of 2-pheny1-1,4-benzopyronemay, which are very abundant in nature, being accumulated in regular human diets including flowers ( Zhang and Ma, 2018 ), fruits ( Chang et al, 2018 ), vegetables, tea, wine ( Matveeva et al, 2018 ), and so on ( Szmitko and Verma, 2005 ). With the basic core scaffold, flavonoids have been demonstrated to exhibit relevant biological properties involving strong activity for anti-oxidant ( Pietta, 2000 ), anti-allergy ( Kawai et al, 2007 ; Castell et al, 2014 ), anti-inflammatory ( Nijveldt et al, 2001 ; Serafini et al, 2010 ; Matias et al, 2014 ), anti-microbial ( Cushnie and Lamb, 2005 ), and anti-obesity ( Hughes et al, 2008 ) effects.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Mechanism of Flavonoids Through Systematic Bioinformatics Analysis

Qiu

Lin-de

et al. 2018

Front. Pharmacol.

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Flavonoids are the largest class of plant polyphenols, with common structure of diphenylpropanes, consisting of two aromatic rings linked through three carbons and are abundant in both daily diets and medicinal plants. Fueled by the recognition of consuming flavonoids to get better health, researchers became interested in deciphering how flavonoids alter the functions of human body. Here, systematic studies were performed on 679 flavonoid compounds and 481 corresponding targets through bioinformatics analysis. Multiple human diseases related pathways including cancers, neuro-disease, diabetes, and infectious diseases were significantly regulated by flavonoids. Specific functions of each flavonoid subclass were further analyzed in both target and pathway level. Flavones and isoflavones were significantly enriched in multi-cancer related pathways, flavan-3-ols were found focusing on cellular processing and lymphocyte regulation, flavones preferred to act on cardiovascular related activities and isoflavones were closely related with cell multisystem disorders. Relationship between chemical constitution fragment and biological effects indicated that different side chain could significantly affect the biological functions of flavonoids subclasses. Results will highlight the common and preference functions of flavonoids and their subclasses, which concerning their pharmacological and biological properties.

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“…These results should be taken in context of the predominantly plant-based diet of the study subject, as previous reports found western, high-fat, low-fiber diet promoted dysbiosis and neuroinflammation in MS (43), while plant-based high-fiber diets decreased MS risks (44). However, prior to the study, while on the high-fiber diet, the subject's symptoms remained troublesome and led to the decision to test FMT.…”

Section: Discussionmentioning

confidence: 64%

Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis

et al. 2020

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Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients.

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Western lifestyle and immunopathology of multiple sclerosis

Cited by 46 publications

References 188 publications

Sleep Abnormalities in Multiple Sclerosis

Sleep Abnormalities in Multiple Sclerosis

Exploring the Mechanism of Flavonoids Through Systematic Bioinformatics Analysis

Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis

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