This work investigates the potential of surface nano-coatings on the heat transfer surface of heat exchangers, in order to improve their overall efficiency in terms of pressure drop and heat power exchanged. The work started from the consideration that, due to the increasingly strict international standards, the machines will be provided with optimized engines with new and improved devices to reduce the exhaust emissions (liquid cooled EGR valves, new catalytic converters and DPF systems) which reduce inevitably the space in the engine compartment. In this paper it is studied the feasibility of the coating processes and the adaptability of deposition techniques to the industrial production process of cross flow heat exchanger fins. The innovative exchanger performance, investigated using dedicated test rigs, shows that the results are influenced by the coating technology. 13.1 Scientific and Industrial Motivations Heat exchanger efficiency is one of the main concerns in trying to improve the overall efficiency of mobile off-road machines and industrial plants. Compact radiators play a fundamental role in temperature control of internal combustion engines (ICE) and hybrid drivelines. An improvement of this component could affect the global efficiency of the machine. Typically, the problem is studied from a geometrical point of view, using different production lines to make fins geometries dedicated to improve the heat exchange or to reduce the pressure drop. Heat exchanger optimization is needed to obtain smaller, lighter, but at the same time more efficient radiators.