Wetting Behavior of Bile Salt–Lipid Dispersions and Dissolution Media Patterned after Intestinal Fluids

Luner, Paul E.; Kamp, Deana VanDer

doi:10.1002/1520-6017(200103)90:3<348::aid-jps10>3.0.co;2-v

Cited by 31 publications

(14 citation statements)

References 54 publications

(68 reference statements)

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“…The effects are especially apparent for poorly soluble lipophilic drugs (68). In addition to solubilization, an improvement in wetting characteristics has been demonstrated (42,69,70). Bile salts and lecithin are major components of the currently used media simulating the conditions in the small intestine.…”

Section: Bile Secretionsmentioning

confidence: 99%

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

et al. 2008

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Section: Bile Secretionsmentioning

confidence: 99%

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

et al. 2008

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“…Forced imbibition involves a combination of capillary phenomena and an externally enforced flow rate or pressure difference. Printing processes Ink penetration in paper [285]; Coating of paper [266,280]; Absorbing materials [301] Food industry Cooking [265]; Wine filtering [333] Biological sciences Fluid transport in plants or imbibition of water into seeds (see Section IV C); Water penetration into soils [33]; Medical applications [204] Surface chemistry Contact angle measurements [58,59,171,215]; Droplets on surfaces [62] Composite materials Invasion of voids by a resin or a metal in filer or metal-metal composites. [8,9,80,92,230,231,232] Textiles Behaviour of garments in the presence of liquids [57,133,134,152,272] Construction Water penetration into concrete or cement pastes [50,195] Although empirical relations for the flow of liquids through a porous medium existed for a long time, an effort, in part inspired by statistical mechanics, to quantitatively understand and predict the flow led to the study of pattern formation or the geometry of the regions occupied by the invading/receding fluids.…”

Section: Introductionmentioning

confidence: 99%

Imbibition in disordered media

Alava

Dubé

Rost

2004

Advances in Physics

289

333

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The physics of liquids in porous media gives rise to many interesting phenomena, including imbibition where a viscous fluid displaces a less viscous one. Here we discuss the theoretical and experimental progress made in recent years in this field. The emphasis is on an interfacial description, akin to the focus of a statistical physics approach. Coarse-grained equations of motion have been recently presented in the literature. These contain terms that take into account the pertinent features of imbibition: non-locality and the quenched noise that arises from the random environment, fluctuations of the fluid flow and capillary forces. The theoretical progress has highlighted the presence of intrinsic length-scales that invalidate scale invariance often assumed to be present in kinetic roughening processes such as that of a two-phase boundary in liquid penetration. Another important fact is that the macroscopic fluid flow, the kinetic roughening properties, and the effective noise in the problem are all coupled. Many possible deviations from simple scaling behaviour exist, and we outline the experimental evidence. Finally, prospects for further work, both theoretical and experimental, are discussed.

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“…Bile acids affect both solubility and dissolution, by a micellization effect. The contents of upper GI tract in the fed state has been characterized as an emulsion, although more detailed examination has shown that it consists of multiple phases [53]. The natural bile salts are surface active and self-associate above a narrow concentration range to form multimers (usually termed micelles) [51].…”

Section: Bile Saltsmentioning

confidence: 99%

“…Luner et al [53] evaluated the effect of various individual lipids and composition of physiologically representative media estimated on the basis of physiologic data. The two former methods are recommended because of their precise and simple set-up and handling.…”

Section: Bio-relevant Dissolution Mediamentioning

confidence: 99%