Infertility is a major cause of psychological burden and women are always held responsible for such especially in Africa. Evidence indicates that male infertility is as common as female infertility in the general population. This study sought to determine the prevalence and associated factors of seminal fluid abnormalities among partners of women presenting with infertility. This was a descriptive, cross–sectional study and the subjects were recruited through convenience sampling. Relevant socio-demographic data were collected using pretested questionnaires. Seminal fluid of each subject was analyzed within 30 minutes of collection assessing the volume, sperm count, motility, morphology, white blood cells count, and microbial profile and sensitivity. The data obtained was analyzed using SPSS version 21. Continuous variables were analyzed using mean and Standard deviation while categorical variables were presented in percentages. Chi–square, Fisher’s Exact Test, correlation analysis and Logistic Regression was used, and the significance level was set at 0.05. Among 150 males analyzed, prevalence of semen abnormalities was 32%. Oligozoospermia was identified in 10% of the subjects out of which 11.3% had severe oligozoospermia while 10.7% had azoospermia. Asthenozoospermia (36%) was the commonest abnormality observed among the subjects. Men 40 years and above (60%), Penile infection (40.7%), and smoking (29.3%) were statistically significant factors associated with semen abnormalities among the study population. Seminal fluid abnormalities are high and asthenozoospermia was the most common. Age ≥ 40 years, penile infections and cigarette smoking are associated with semen abnormalities in our environment.