What Accounts for the Interindividual Variability of sIgA Concentration in Saliva?

Kügler, Joachim; Hess, Markus; Haake, D.

doi:10.1111/j.1749-6632.1993.tb18369.x

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…The results of this study demon- strate that total salivary IgA concentrations are temporarily decreased during excavation of a caries lesion. Saliva flow has been identified to be a potential modulator for salivary IgA concentration: high saliva fiow corresponds to a low salivary IgA concentration (15)(16)(17)(18). However, in this study, saliva flow was not significantly changed during or after the excavation of a caries lesion.…”

Section: Discussionmentioning

confidence: 56%

Excavation of caries lesions induces transient decrease of total salivary immunoglobulin A concentration

Kügler

Breitfeld

Tewes

et al. 1996

European J Oral Sciences

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Salivary immunoglobulin A (IgA) secreted by salivary glands is the predominant humoral factor of the local immune system in the oral cavity. Epidemiological studies emphasize the importance of salivary IgA in the protection from infections and caries. This study investigated how excavation of caries lesions affects total salivary IgA concentration. Fifteen patients were assigned to two sessions: the first session consisted of the excavation of a caries lesion. Thirty min before, during, directly after, and 30 min after the excavation, patients were asked for saliva samples. One wk later, a control session was performed on the same patients at the same time of the day, consisting of a dental inspection without any drilling. Marked, transient decreases were observed in concentration and secretion rate of total salivary immunoglobulin A during and immediately after caries excavation. Thirty min after caries excavation, immunoglobulin A concentrations returned to baseline. No differences were found between sessions with regard to saliva flow and cortisol concentration. It was concluded that transient decreases of total salivary immunoglobulin A concentrations are induced by excavation of caries lesions.

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Section: Discussionmentioning

confidence: 56%

Excavation of caries lesions induces transient decrease of total salivary immunoglobulin A concentration

Kügler

Breitfeld

Tewes

et al. 1996

European J Oral Sciences

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“…There is also accumulating evidence indicating that the immune cells have receptors for these hormones, which supports the hypothesis that they are involved in immune modulation (see review by Rabin et al, 1989;O'Leary, 1990;Ader et al, 1991;Ader and Felten, 1995;Weigent and Blalock, 1995;Bedovsky and Rey, 1996). Some of the studies reviewed above did assess catecholamine (McClelland et al, 1985;Kugler et al, 1992Kugler et al, , 1993 and cortisol (Evans et al, 1994). Although changes in these hormones were observed in parallel to changes in s-IgA, it is not clear if these hormonal changes accounted for or contributed to the stress-induced changes in s-IgA, since the investigators either found no relation between their hormonal measures and their measurers of s-IgA or did not examine whether the immune changes were due to the hormonal changes.…”

Section: Discussionmentioning

confidence: 85%

Psychosocial Factors and Secretory Immunoglobulin A

Valdimarsdottir

Stone

1997

Critical Reviews in Oral Biology & Medicine

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This review focuses on studies that have examined the relation between psychosocial factors and secretory immunoglobulin A (s-IgA). Several studies have examined the relation between s-IgA and stressful circumstances ranging from major life events to minor daily events. The findings from these studies were often contradictory, since different experimenters reported different stress-related changes in s-IgA. The effects of stress reduction interventions, such as relaxation and imagery, on s-lgA levels have also been examined. Although these studies indicate that various interventions are associated with increases in s-lgA levels, methodological refinements are needed before more definitive conclusions can be made. The possibility that the relation between stress and s-IgA may be moderated by personality characteristics or mediated by psychological distress was supported in some studies. The review concludes with suggestions for future research.

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“…As salivary IgA is a general indicator of the defensive abilities of the mucosal immune system rather than a direct marker of infection (Mestecky, 1993), it reacts to a wide variety of potential stressors beyond disease ecology, including mood, stress hormones, socioeconomic status, and age (Kugler et al, 1993, Evans et al, 2000. Because of its geographical size, Karare may be more heterogeneous than the other two communities potentially increasing variation in infant immune development.…”

Section: Discussionmentioning

confidence: 99%

“…Since the statistical model used here only accounts for 8.4% of the total variation found in infant salivary IgA, there are likely other significant predictors that play a role in explaining this system. As salivary IgA is a general indicator of the defensive abilities of the mucosal immune system rather than a direct marker of infection (Mestecky, 1993), it reacts to a wide variety of potential stressors beyond disease ecology, including mood, stress hormones, socioeconomic status, and age (Kugler et al, 1993, Evans et al, 2000. Future research should address other causes of variation in the infant salivary IgA system.…”

Section: Discussionmentioning

confidence: 99%

Brief communication: Chronic undernutrition is associated with higher mucosal antibody levels among ariaal infants of northern kenya

Miller

McConnell

2012

American J Phys Anthropol

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The immune activation that occurs with infection diverts energy from growth and can contribute to poor nutritional outcomes in developing infants and children. This study investigates the association between salivary immunoglobulin A (IgA) levels and growth outcomes among Ariaal infants of northern Kenya. The Ariaal are a group of settled northern Kenyan pastoralists who are under considerable nutritional stress. Two hundred and thirty-nine breastfeeding Ariaal infants were recruited into the study and underwent anthropometric measurement and saliva collection, with mothers providing individual and household characteristics for them via questionnaire. Infant saliva samples were analyzed with an ELISA for IgA in the United States. Infant anthropometric measurements were converted to height-for-age z-scores (HAZ) using the WHO Child Growth Standards. Based on multivariate models performed in SAS 9.2 two main results emerge: 1) low HAZ, an indicator of chronic undernutrition, was significantly associated with higher IgA concentration (β = -0.12, P = 0.050) and 2) boys had significantly higher IgA levels than girls (β = 0.25, P = 0.039). Although there was not a significant interactive effect between HAZ and sex, the two variables confound each other, with boys having significantly lower HAZ values than girls do. In addition, maternal breastmilk IgA was significantly associated with infant salivary IgA, indicating that maternal effects play a role in infant IgA development. Future research will unravel the three-way association between sex, stunting, and immune function in the Ariaal community.

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What Accounts for the Interindividual Variability of sIgA Concentration in Saliva?

Cited by 6 publications

References 4 publications

Excavation of caries lesions induces transient decrease of total salivary immunoglobulin A concentration

Excavation of caries lesions induces transient decrease of total salivary immunoglobulin A concentration

Psychosocial Factors and Secretory Immunoglobulin A

Brief communication: Chronic undernutrition is associated with higher mucosal antibody levels among ariaal infants of northern kenya

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